Evaluation of galectin-3 levels in patients with type 2 diabetes mellitus and chronic kidney disease

Souza, Isabella D P de; Rodrigues, Kathryna Fontana; Pietrani, Nathalia Teixeira; Bosco, Adriana; Gomes, Karina Braga; Alves, Michelle Teodoro

doi:10.5935/1676-2444.20210010

Jornal Brasileiro De Patologia E Medicina Laboratorial

2021

DOI: 10.5935/1676-2444.20210010

|View full text |Cite

Evaluation of galectin-3 levels in patients with type 2 diabetes mellitus and chronic kidney disease

Isabella D P de Souza

Kathryna Fontana Rodrigues

Nathalia Teixeira Pietrani

et al.

Abstract: The history of muscle biopsy dates back to 1860, when Duchenne first performed a biopsy on a patient with symptoms of myopathy (1) . Since then, the basic and clinical science of muscle and muscle disease has gone through three stages of development: the classical period, the modern stage and the molecular era.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Galectin-3 as a prognostic biomarker for diabetic nephropathy

Mohamed,

Marie,

Abouraya

et al. 2022

The Scientific Journal of Al-Azhar Medical Faculty, Girls

View full text Add to dashboard Cite

Background Diabetes mellitus (DM) type 2 is a major health condition that has shown an increased incidence globally. The most common complication in type 2 DM is diabetic nephropathy (DN). Aim To determine serum galectin-3 as a prognostic biomarker in type 2 DN. Patients and methods A case–control prospective study was done in the Internal Medicine Department of AL-Zahraa University Hospital, Cairo, Egypt. The study was conducted on 90 patients, including 60 patients with type 2 DM and 30 age-matched and sex-matched healthy volunteers as a control group. The 90 patients were classified into four groups: group I included 20 diabetic patients (type 2) with an albumin/creatinine ratio (ACR) of less than 30 mg/g (normoalbuminuria), group II included 20 DM (type 2) with an ACR of 30–300 mg/g (microalbuminuria), group III included 20 DM (type 2) with an ACR of more than 300 mg/g (macroalbuminuria), and control group included 30 age-matched and sex-matched healthy individuals. History, examination, fasting blood sugar, glycated hemoglobin, urea, creatinine, estimated glomerular filtration rate, ACR, lipid profile, and serum galectin-3 were done for all participants. The study was approved by the Al Azhar University Ethics Board. Results Galectin-3 was significantly higher in patients with macroalbuminuria than in those with microalbuminuria and normoalbuminuria. Galectin-3 level has a significant positive correlation with parameters of DN progression (age, DM duration, fasting blood sugar, glycated hemoglobin, cholesterol, low-density lipoprotein, triglyceride, urea, creatinine, and ACR) and a significant negative correlation with estimated glomerular filtration rate and high-density lipoprotein levels. Conclusion Galectin-3 was significantly higher in type 2 diabetic patients with macroalbuminuria than in those with microalbuminuria and normoalbuminuria.

show abstract

Galectin-3 as a prognostic biomarker for diabetic nephropathy

Mohamed,

Marie,

Abouraya

et al. 2022

The Scientific Journal of Al-Azhar Medical Faculty, Girls

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

334 Leonard St

Brooklyn, NY 11211

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Evaluation of galectin-3 levels in patients with type 2 diabetes mellitus and chronic kidney disease

Cited by 1 publication

References 0 publications

Galectin-3 as a prognostic biomarker for diabetic nephropathy

Galectin-3 as a prognostic biomarker for diabetic nephropathy

Contact Info

Product

Resources

About