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Cited by 4 publications
(4 citation statements)
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“…However, specificity and selectivity for NQO1 depend on cytotoxicity that can be achieved only within a relatively short dose range and within a short period of time [ 33 ]. The chronic exposure of mice to the compound can produce unpredictable toxic effects in high doses, time, and frequency of exposure [ 34 ]. In order to prevent possible toxicity, given that there is a higher frequency of administration and for a longer time considering a possible clinical usage, we sought to evaluate if lower doses would be effective in a longer period of time in the posttreatment of the CLP.…”
Section: Discussionmentioning
confidence: 99%
“…However, specificity and selectivity for NQO1 depend on cytotoxicity that can be achieved only within a relatively short dose range and within a short period of time [ 33 ]. The chronic exposure of mice to the compound can produce unpredictable toxic effects in high doses, time, and frequency of exposure [ 34 ]. In order to prevent possible toxicity, given that there is a higher frequency of administration and for a longer time considering a possible clinical usage, we sought to evaluate if lower doses would be effective in a longer period of time in the posttreatment of the CLP.…”
Section: Discussionmentioning
confidence: 99%
“…Due to its antioxidant, biocompatibility, bioadhesion and action against free radicals, chitosan offers an excellent potential to be used as phytoprotective, cytoprotective and genoprotective agent against toxic agrochemicals [23,108]. Agrochemicals have been widely known to cause phytotoxic, cytotoxic and genotoxic effects on the plant, cell and DNA, respectively [109,110].…”
Section: Phytoprotection Cytoprotection and Genoprotection Of Chitosanmentioning
confidence: 99%
“…The studies on the β-lapachone connected with chitosan confirms the decrease of agent toxicity. This fact increases the probability of its application in the pharmaceutical industry [ 313 , 314 ]. According to Pereira et al [ 315 ], starch could be used as a lapachol carrier in drug delivery systems.…”
Section: Lapacholmentioning
confidence: 99%