The role of cytogenetics and molecular biology in the diagnosis, treatment and
            monitoring of patients with chronic myeloid leukemia

Dorfman, Luiza Emy; Floriani, Maiara Anschau; Oliveira, Tyana Mara R. D. R.; Cunegatto, Bibiana; Rosa, Rafael Fabiano Machado; Zen, Paulo Ricardo Gazzola

doi:10.5935/1676-2444.20180015

Cited by 11 publications

(16 citation statements)

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“…The presence of the Ph chromosome should be monitored by conventional cytogenetic analysis to obtain complete cytogenetic response (CCR) or molecular response (MR) by analysis of transcription levels of BCR-ABL1 by RT-PCR and can correlate with prognosis[ 32 , 69 , 70 ]. The FISH is recommended for diagnosis in cases where the Ph chromosome is not detected by classical cytogenetics.…”

Section: Diagnosismentioning

confidence: 99%

“…Considering that FISH can quantify proliferating neoplastic cells in metaphase and non-proliferating cells in interphase, it used to be used for diagnosis and to analyze response to therapy using either peripheral blood or BM[ 72 ]. However, this technique has been replaced and it can only substitute chromosomal analysis in CML monitoring if BM cells are not obtained and/or for the definition of complete cytogenetic remission (CCyR)[ 69 ]. In addition, in patients with atypical transcripts, its use may be necessary for monitoring disease progression[ 41 ].…”

Section: Diagnosismentioning

confidence: 99%

“…Patients with rapid cytogenetic or molecular remission (before 3 mo) and CCyR have a favorable prognosis[ 73 ]; more than 70% of them remain alive after 10 years. Karyotype is crucial in post-remission therapy decisions and molecular factors will determine treatment in individuals with normal karyotype[ 69 ].…”

Section: Diagnosismentioning

confidence: 99%

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Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs: A literature review

Sampaio

Santos

Marques

et al. 2021

WJCO

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Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly ― the presence of the Philadelphia chromosome. The advances in cytogenetic and molecular assays are of great importance to the diagnosis, prognosis, treatment, and monitoring of CML. The discovery of the breakpoint cluster region (BCR)-Abelson murine leukemia (ABL) 1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein. Tyrosine kinase inhibitors (known as TKIs) are the standard therapy for CML and greatly increase the survival rates, despite adverse effects and the odds of residual disease after discontinuation of treatment. As therapeutic alternatives, the subsequent TKIs lead to faster and deeper molecular remissions; however, with the emergence of resistance to these drugs, immunotherapy appears as an alternative, which may have a cure potential in these patients. Against this background, this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context.

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Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

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Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs: A literature review

Sampaio

Santos

Marques

et al. 2021

WJCO

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“…O conhecimento sobre a LMC adveio conjuntamente ao avanço de técnicas analíticas em citogenética humana, já que nesta leucemia se encontra a primeira mutação cromossômica ligada ao câncer, o cromossomo Ph, o qual é utilizado como marcador de LMC (DORFMAN et al, 2018).…”

Section: Citogenéticaunclassified

“…Estas variantes simples incluem um ou mais cromossomos além do 9 e 22, mas sempre modificando o cromossomo 22. Alterações secundárias ou outros rearranjos cromossômicos crípticos complexos em BCR-ABL1 podem ser vistos em pacientes com LMC com cariótipo normal (DORFMAN et al, 2018).…”

Section: Simões 2008)unclassified

Métodos Laboratoriais Utilizados Para O Diagnóstico Das Leucemias - Uma Revisão Bibliográfica

Frota¹,

Sousa²,

Ferreira³

et al. 2021

Ciências Médicas: Estudos Clínicos E Revisões Bibliográficas

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A constante evolução da pesquisa na área da saúde está refletida nos avanços das ciências médicas, em que o diagnóstico, o conhecimento sobre antigas e novas doenças e até mesmo a nossa própria atuação e vivências como profissionais estão em permanente status de atualização.O presente livro contém 23 capítulos elaborados por autores pesquisadores da área das ciências médicas e áreas afins. Estando as nossas vidas tão marcadas pela pandemia (ainda em curso) da covid-19 e sendo este livro uma obra que trata sobre saúde, vida e doença, o tema covid-19 corresponde, oportunamente, ao maior número de capítulos.Acredito que esta obra multidisciplinar representa uma importante contribuição para as ciências médicas, especialmente como fonte de revisão e atualização para nós, acadêmicos e profissionais da área.Em nossos livros selecionamos um dos capítulos para premiação como forma de incentivo para os autores, e entre os excelentes trabalhos selecionados para compor este livro, o premiado foi o capítulo 17, intitulado "MÉTODOS LABORATORIAIS UTILIZADOS PARA O DIAGNÓS-TICO DAS LEUCEMIAS: UMA REVISÃO BIBLIOGRÁFICA".

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Control of Ph+ and additional chromosomal abnormalities in chronic myeloid leukemia by tyrosine kinase inhibitors

Ansari

Verma

2023

Med Oncol

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The role of cytogenetics and molecular biology in the diagnosis, treatment and monitoring of patients with chronic myeloid leukemia

Cited by 11 publications

References 0 publications

Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs: A literature review

Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs: A literature review

Métodos Laboratoriais Utilizados Para O Diagnóstico Das Leucemias - Uma Revisão Bibliográfica

Control of Ph+ and additional chromosomal abnormalities in chronic myeloid leukemia by tyrosine kinase inhibitors

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