Clinical and laboratory diagnosis of Zika fever: an update

Xavier, Analúcia Rampazzo; Kanaan, Salim; Bozzi, Ronielly P.; Amaral, Luiza V.

doi:10.5935/1676-2444.20170039

Cited by 7 publications

(6 citation statements)

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“…The similarities between the values of blood components and platelets according to the status of maternal infection led us to consider the possibility of false negative results among pregnant women with non-positive results for ZIKV attested by RT-PCR, since they presented symptoms similar to ZIKV-positive pregnant women, but some with a test time of longer than 15 days. The possibility of infection, even with negative results in urine and blood samples tested by RT-PCR, cannot be disregarded, nor can the sensitivity and specificity values of the test, especially in areas endemic for arboviruses [41].…”

Section: Discussionmentioning

confidence: 99%

Hematological Profile of Pregnant Women with Suspected Zika Virus Infection Followed Up at a Referral Service in Manaus, Brazil

Andrade

Gonçalves

Redivo

et al. 2021

Viruses

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The purpose of this paper is to describe the hematological profile of pregnant women with suspected Zika virus (ZIKV) infection followed up at a reference service for infectious diseases in Manaus, Brazil, through a clinical, epidemiological, cross-sectional study of pregnant women with an exanthematic manifestation who looked for care between 2015 and 2017. The participants were 499 pregnant women, classified into four subgroups, according to laboratory confirmation of infections: ZIKV-positive; ZIKV-positive and positive for another infection; positive for another infection but not ZIKV-positive; and not positive for any of the infections investigated. Hematological parameters were analyzed descriptively. The association between maternal infection and the hematological profile, along with the association between the maternal hematological profile and the gestational outcome, were tested. Similar hematic and platelet parameters were observed among pregnant women. However, a significant association was observed between low maternal lymphocyte count and a positive diagnosis for ZIKV (p < 0.001). The increase in maternal platelet count and the occurrence of unfavorable gestational outcome were positively associated. A similar hematic and platelet profile was identified among pregnant women, differing only in the low lymphocyte count among ZIKV-positive pregnant women. Regarding gestational outcomes, in addition to the damage caused by ZIKV infection, altered maternal platelets may lead to unfavorable outcomes, with the need for adequate follow-up during prenatal care.

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Section: Discussionmentioning

confidence: 99%

Hematological Profile of Pregnant Women with Suspected Zika Virus Infection Followed Up at a Referral Service in Manaus, Brazil

Andrade

Gonçalves

Redivo

et al. 2021

Viruses

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“…As a response to the challenges linked to the conventional diagnostic of Zika virus (polymerase chain reaction-PCR) [18], Kaushik et al [6] developed an electrochemical immunosensor by means of the immobilization of a specific Zika virus-envelop protein antibody on a monolayer of dithiobis (succinimidyl propionate) (DTSP) deposited on a gold interdigitated microelectrode. The authors performed the technique of Electrochemical Impedance Spectroscopy (EIS) to monitor the charge transfer resistance (R ct ) resultant from the interaction between the immobilized antibody and the Zika antigen.…”

Section: Zikamentioning

confidence: 99%

Current Progresses in the Development of Biosensors for the Diagnosis of Neglected Tropical Diseases

Borges

Fiel

Vasconcellos

et al. 2020

Systematic Bioscience and Engineering

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The World Health Organization classifies neglected tropical diseases (NTDs) in order to highlight the impact of these diseases on public health and as a tool to eradicate them. Due to its risk to human health, especially in the last decade, several publications have been dedicated to the proposal of alternative diagnosis for NTDs. The rapid detection of these diseases is essential for the early initiation of treatment and, thus, allows the reduction of mortality and improves the quality of life of patients. However, the conventional techniques used to detect NTDs are expensive, time-consuming and require more sophisticated equipment in the laboratory, which hinders analyzes to be performed in situ. In light of this context, researchers have been working on the application of biosensors to overcome the current problems. The results found have been promising, as the biosensors exhibited low detection limits with high selectivity and the possibility of performance in miniaturized/portable systems. This technology combines the specificity of biological probes with the sensitivity and stability of several groups of transducers (mainly electrochemical and optical ones). In the present manuscript, we reviewed the recent advances in the field of biosensors to detect some of the main pathogens causing NTDs worldwide (Zika, dengue, schistosomiasis, malaria, snakebite envenoming, leishmaniasis and Chagas disease).

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“…After ZIKV has incubated for around 3–12 days, there are some common symptoms of ZIKV infection, such as fever, headache, arthralgia, conjunctivitis, myalgia, and rash 57,95,98‐113 . In addition, there are some other less common symptoms, including abdominal pain, diarrhea, anorexia, dizziness, and constipation 98,114‐123 . Fortunately, most individuals infected by ZIKV only suffer from mild or no symptoms.…”

Section: Introductionmentioning

confidence: 99%

Recent progresses and remaining challenges for the detection of Zika virus

Zhang

Chen

et al. 2021

Medicinal Research Reviews

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Zika virus (ZIKV) has emerged as a particularly notorious mosquito‐borne flavivirus, which can lead to a devastating congenital syndrome in the fetuses of pregnant mothers (e.g., microcephaly, spasticity, craniofacial disproportion, miscarriage, and ocular abnormalities) and cause the autoimmune disorder Guillain‐Barre' syndrome of adults. Due to its severity and rapid dispersal over several continents, ZIKV has been acknowledged to be a global health concern by the World Health Organization. Unfortunately, the ZIKV has recently resurged in India with the potential for devastating effects. Researchers from all around the world have worked tirelessly to develop effective detection strategies and vaccines for the prevention and control of ZIKV infection. In this review, we comprehensively summarize the most recent research into ZIKV, including the structural biology and evolution, historical overview, pathogenesis, symptoms, and transmission. We then focus on the detection strategies for ZIKV, including viral isolation, serological assays, molecular assays, sensing methods, reverse transcription loop mediated isothermal amplification, transcription‐mediated amplification technology, reverse transcription strand invasion based amplification, bioplasmonic paper‐based device, and reverse transcription isothermal recombinase polymerase amplification. To conclude, we examine the limitations of currently available strategies for the detection of ZIKV, and outline future opportunities and research challenges.

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Clinical and laboratory diagnosis of Zika fever: an update

Cited by 7 publications

References 0 publications

Hematological Profile of Pregnant Women with Suspected Zika Virus Infection Followed Up at a Referral Service in Manaus, Brazil

Hematological Profile of Pregnant Women with Suspected Zika Virus Infection Followed Up at a Referral Service in Manaus, Brazil

Current Progresses in the Development of Biosensors for the Diagnosis of Neglected Tropical Diseases

Recent progresses and remaining challenges for the detection of Zika virus

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