Angiosarcoma of small intestine: case report and literature review

Lopes, Roberto Heleno; Resende, Frederico Augustus Martins de; J, Fraga; Oliveira, Alexandre F; Pereira, M. S.; Maciel, Bruno A. R.; Lamim, Raul Fernando B.

doi:10.5935/1676-2444.20160054

Cited by 4 publications

(5 citation statements)

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“…The prognosis was much worse for patients with small intestine angiosarcomas than those with tumors of any other site, and over one-year survival time is extremely rare [28]. Most patients did not survive the post-operative period or died within a few months after diagnosis.…”

Section: Resultsmentioning

confidence: 99%

Clinical Characteristics and Prognostic Factors of Small Intestine Angiosarcoma: a Retrospective Clinical Analysis of 66 Cases

Ouyang

Xiao

et al. 2017

Cell Physiol Biochem

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Background/Aims: Primary angiosarcoma of the small intestine is a rare neoplasia, and there are limited data from systematic analyses. The aim of this study is to describe the clinical and pathological characteristics in addition to the prognostic factors for this rare neoplasia. Methods: We retrospectively collected the clinical records and prognostic information of 66 patients with small intestine angiosarcoma reported between 1970 and 2017. We used the Chi-square test, the log-rank test, and Cox regression analyses to evaluate the data. Results: There were 66 patients diagnosed with small intestine angiosarcoma. The onset age ranged from 24–92 years old. There were 24 patients diagnosed before the year 2000, and 42 patients were diagnosed after 2000. The data indicated that 49 cases were diagnosed as primary disease, and the remaining 15 cases were secondary disease. The main clinical symptoms were nonspecific and included gastrointestinal (GI) bleeding and abdominal pain. Additionally, we found multi-center foci were one of the characteristics of this disease. Radiation-induced small intestine angiosarcoma (RSIA) is a special type of disease with a similar prognosis. This type was more frequent in females and decreased after the year 2000. We also found that GI bleeding was less common in RSIA cases. The log-rank test results revealed that old-age, poor differentiation, and GI bleeding were associated with worse prognosis. Surgical treatment showed a trend toward a prolonged survival time. However, the result was not statistically significant. Our results show treatment with adjuvant therapy improved prognosis. The multivariate Cox analysis demonstrated adjuvant therapy was an independent indicator of a favorable outcome in small intestine angiosarcoma patients. Conclusion: Pay attention to the unexplained gastrointestinal bleeding could lead to a faster diagnosis and control of small intestine angiosarcoma. Furthermore, treatments including adjuvant therapy can effectively improve the prognosis.

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Section: Resultsmentioning

confidence: 99%

Clinical Characteristics and Prognostic Factors of Small Intestine Angiosarcoma: a Retrospective Clinical Analysis of 66 Cases

Ouyang

Xiao

et al. 2017

Cell Physiol Biochem

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“…The primary angiosarcoma of the small bowel like other neoplasms on this location present with nonspecific symptomatology that may include abdominal pain, nausea, vomiting, intestinal obstruction, gastrointestinal bleeding and anemia [2,4].…”

Section: Discussionmentioning

confidence: 99%

“…This case is the one with the highest survival described in literature in patients with this disease. Most patients die within a few months after diagnosis with an average survival from two to six months after diagnosis secondary to refractory bleeding and disease progression [2,3,6,[10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, like other tumors of the small bowel, angiosarcomas have nonspecific symptoms including recurrent gastrointestinal bleeding, abdominal pain and nausea [2,[5][6][7]. The few cases described in the literature report rapid dissemination and very reserved prognosis with average survival from two to six months after diagnosis [3,6].…”

Section: Introductionmentioning

confidence: 99%

“…Rare cases are described in heart, liver, spleen and adrenal glands, being the digestive tract localization an exceptionally rare occurrence [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary angiosarcoma of the small bowel: A case report

Sousa¹,

Viveiros²,

Fernandes³

et al. 2017

Case Rep Int

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Introduction: Small bowel angiosarcomas are exceedingly rare neoplasms with unspecific symptomatology which may lead to a delay in the diagnosis and consequently a worst prognosis. Case Report: A 73-year-old male patient presented with nausea, vomiting and abdominal pain. The blood test showed a mild anemia. Computed tomography (CT) scan revealed an ileal tumor. The patient was submitted to an exploratory laparotomy and segmental enterectomy. Pathology findings described an angiosarcoma. The patient had disease progression and died after two months. Conclusion: Angiosarcomas are high grade rapidly progressive neoplasms and have a very poor prognosis with a high mortality rate. The average life expectancy is 2-6 months after diagnosis.

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Angiosarcoma gastrointestinal multifocal, con compromiso extenso de estómago, intestino delgado y colon. Reporte de un caso

et al. 2022

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Introducción. El angiosarcoma es una neoplasia vascular originada a nivel del endotelio, de baja frecuencia, conocido por su agresividad y crecimiento acelerado. Alcanza solo el 1 al 2 % del total de los sarcomas. La presentación gastrointestinal es infrecuente y su incidencia es poco conocida debido al escaso reporte de casos en la literatura. Suele identificarse en etapas avanzadas debido a la dificultad del diagnóstico histopatológico por sus características morfológicas, siendo necesario aplicar tinciones especiales o estudio inmunohistoquímico. Caso clínico. Por su interés y singularidad, presentamos el caso de un paciente masculino de 54 años, quien consultó con hemorragia digestiva profusa, anemización y requerimiento de terapia transfusional. Resultados. Durante el proceso diagnóstico, en la endoscopia encontraron diversas lesiones multifocales que se extendían por gran parte del tracto gastrointestinal. El estudio histopatológico mostró angiosarcoma gastrointestinal. Discusión. El angiosarcoma del tracto gastrointestinal es extremadamente infrecuente, de difícil diagnóstico y bajas posibilidades de manejo curativo, con opciones terapéuticas limitadas, lo que configura un mal pronóstico a corto plazo.

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Angiosarcoma of small intestine: case report and literature review

Cited by 4 publications

References 1 publication

Clinical Characteristics and Prognostic Factors of Small Intestine Angiosarcoma: a Retrospective Clinical Analysis of 66 Cases

Clinical Characteristics and Prognostic Factors of Small Intestine Angiosarcoma: a Retrospective Clinical Analysis of 66 Cases

Primary angiosarcoma of the small bowel: A case report

Angiosarcoma gastrointestinal multifocal, con compromiso extenso de estómago, intestino delgado y colon. Reporte de un caso

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