suPAR in the assessment of post intensive care unit prognosis: a pilot
            study

Silvestre, Joana; Coelho, Luís; Pereira, João; Mendes, Vitor; Tapadinhas, Camila; Póvoa, Pedro

doi:10.5935/0103-507x.20180062

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…Su-PAR and PAI-1 concentrations were higher in critically ill patients compared to healthy volunteers. Another study by Silvestre et al, 20 found that, SOFA was independently associated with a higher risk of in-hospital mortality, 28day mortality and 90-day mortality.…”

Section: Discussionmentioning

confidence: 92%

Thrombo-inflammatory biomarkers to predict sepsis outcome

Efat

Shoeib

Arafa

et al. 2021

Int J Immunopathol Pharmacol

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Background: Sepsis has been redefined recently as life-threatening organ dysfunction caused by dysregulated host responses to infection and septic shock. Soluble urokinase plasminogen activator receptor (SuPAR) and plasminogen activator inhibitor-1(PAI-1) concentration positively correlate to the activation level of the immune system, and are markers of disease severity and aggressiveness. Objective: The study aimed to identify the blood level of plasminogen activator inhibitor-1 (PAI-1) and soluble urokinase plasminogen activator receptor (SuPAR) in sepsis and its association with mortality. Patient and methods: This is an observational prospective study that enrolled 60 adult patients with sepsis (according to SOFA), admitted to Menoufia and Zagazig university hospitals during the period from December 2019 till October 2020. Plasminogen activator inhibitor-1 (PAI-1) and soluble urokinase plasminogen activator receptor (SuPAR) were checked in all participants. Results: SuPAR and PAI.1 were significant independent predictors of hospital mortality. SuPAR showed sensitivity 100%, specificity 95.9%, and accuracy 94% for prediction of early mortality at a cutoff value of 13.4(pg/ml). While, PAI-1 demonstrated sensitivity 100%, specificity 93.9%, and accuracy of 95% at a cutoff value of 122.5 for predicting mortality. Conclusion: PAI-1 and suPAR were significant predictors of hospital mortality among sepsis patients. The sample size was relatively small, which may have decreased the statistical power of the results of the present study. Hence, additional studies with large sample sizes are required for further validation of the present results.

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Section: Discussionmentioning

confidence: 92%

Thrombo-inflammatory biomarkers to predict sepsis outcome

Efat

Shoeib

Arafa

et al. 2021

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

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“…As the urokinase receptor system regulates the confluence of inflammatory, immune, coagulation, and fibrinolytic responses, suPAR has been used in the diagnosis and prognosis of multiple inflammatory, infectious, autoimmune, neoplastic conditions, as well as coronary heart disease and heart failure. [1][2][3][4][5][6][7][8][9][10] Regardless of the underlying pathology, serum levels are raised in acutely ill patients, and also have a prognostic value as they predict high mortality. 6 As the biochemical and molecular mechanisms underpinning these properties remain unclear, suPAR is currently considered a non-specific biomarker for disease presence, progression, and severity.…”

Section: Introductionmentioning

confidence: 99%

Serum soluble urokinase plasminogen activator receptor as a biomarker for distinguishing Kawasaki disease from infections in febrile children

Narchi

George

Alsuwaidi

2023

Preprint

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Background: The soluble form of the urokinase plasminogen activator receptor (SuPAR) is a potential biomarker in various inflammatory, infectious, and autoimmune conditions. Objectives: In this stusy, we aimed to evaluate its diagnostic utility in febrile children to distinguish between Kawasaki disease (KD) and infections, and to investigate any association with the development of coronary artery aneurysms (CAA) KD. Methods: In this retrospective observational cohort study we enrolled 17 children with fever lasting more than 5 days and without suggestive diagnostic signs on admission to hospital. Serum SuPAR concentrations were measured on admission and compared between children with confirmed KD and those with infections, as well as between children with KD who did or did not develop CAA. Results: KD was later confirmed in seven children (median age 25 months), and febrile infections in 10. There was no significant difference in mean (SD) suPAR concentrations between both groups: 5.35 (2.76) ng/mL in KD, and 5.57 (1.69) ng/mL in febrile infections (p=0.84). The best cut-off value for suPAR, 7.74 ng/mL, was the best to correctly classify 64.7% of the cases, with a sensitivity of 28.6% and specificity of 90%. However, it had a low diagnostic performance (Youden index 18.6%, area under the curve curve 60%), and therefore failed to differentiate between KD and infections. In the seven children with KD, only one child developed CAA (SuPAR 4.69 ng/mL) while six other did not, SuPAR 5.47 (1.04) ng/mL) but the statistical significance could not be computed. Conclusion: In febrile children, serum suPAR concentrations failed to distinguish between KD and infections, and were not associated with the development of CAA in KD. Therefore, SuPAR is not a useful biomarker in the diagnosis or prognosis of KD.

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suPAR in the assessment of post intensive care unit prognosis: a pilot study

Cited by 2 publications

References 36 publications

Thrombo-inflammatory biomarkers to predict sepsis outcome

Thrombo-inflammatory biomarkers to predict sepsis outcome

Serum soluble urokinase plasminogen activator receptor as a biomarker for distinguishing Kawasaki disease from infections in febrile children

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