2018
DOI: 10.5935/0103-507x.20180054
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Abstract: ObjectiveTo evaluate whether early initiation of renal replacement therapy is associated with lower mortality in patients with acute kidney injury compared to delayed initiation.MethodsWe performed a systematic review and meta-analysis of randomized controlled trials comparing early versus delayed initiation of renal replacement therapy in patients with acute kidney injury without the life-threatening acute kidney injury-related symptoms of fluid overload or metabolic disorders. Two investigators extracted the… Show more

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Cited by 14 publications
(7 citation statements)
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“…On the contrary, Moreira et al found an increased risk of catheter-related bloodstream infection when renal replacement therapy was initiated early. Moreira FT, et al [10] our study doesn’t confirm this finding.…”
Section: Discussioncontrasting
confidence: 79%
“…On the contrary, Moreira et al found an increased risk of catheter-related bloodstream infection when renal replacement therapy was initiated early. Moreira FT, et al [10] our study doesn’t confirm this finding.…”
Section: Discussioncontrasting
confidence: 79%
“…However, a considerable proportion of the included studies in these three reviews were non-RCTs, meaning that the data were prone to confounding factors. Another two meta-analyses with TSA of RCTs conducted by Moreira et al and Feng et al failed to establish sufficient and conclusive evidences, because the cumulative Z curve did not cross the conventional boundary, the trial sequential monitoring boundary and the futility boundary, and the required information size was not reached [ 33 , 34 ]. However, in our meta-analysis, the cumulative Z curve crossed the futility boundaries, suggesting the results that early initiation of RRT was not associated with a lower mortality were reliable.…”
Section: Discussionmentioning
confidence: 99%
“…The appropriate time to initiate RRT in a critical care setting has not been defined [20]. Studies on the issues of early versus delayed initiation of RRT show heterogeneous results in a critical care setting [2123]. In the case of OHCA treated with TTM, studies on early initiation of RRT have not yet been conducted.…”
Section: Discussionmentioning
confidence: 99%