2016
DOI: 10.5935/0103-5053.20160128
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Abstract: A series of the new urea derivatives with antinociceptive activity has been chromatographically evaluated using reversed phase materials: Zorbax Extend-C18, Cogent UDC Cholesterol with organic-aqueous eluent systems with two organic modifiers (methanol and acetonitrile). The chromatographic lipophilicity parameters: log k w , S and j 0 were determined basing on linear relationship between log k values and concentration of organic mobile phase modifier. The structure-retention studies revealed that the retentio… Show more

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Cited by 2 publications
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“…The extent to which a drug can penetrate biological membranes, such as the blood–brain barrier, cell membranes, and skin, depends heavily on the logP. A number of groups publish the lipophilicity parameters of many newly synthesized drug candidates [167–180]. In drug discovery research, the LSS model is often used to obtain the logP, but Hawrył et al.…”
Section: Methodsmentioning
confidence: 99%
“…The extent to which a drug can penetrate biological membranes, such as the blood–brain barrier, cell membranes, and skin, depends heavily on the logP. A number of groups publish the lipophilicity parameters of many newly synthesized drug candidates [167–180]. In drug discovery research, the LSS model is often used to obtain the logP, but Hawrył et al.…”
Section: Methodsmentioning
confidence: 99%