Microwave-Assisted Synthesis ofN-Heterocycles and Their Evaluation Using an Acetylcholinesterase Immobilized Capillary Reactor

Highly efficient, one-pot synthesis of novel bis-spirooxindoles with skeletal diversity via sequential multi-component reaction in PEG-400 as a biodegradable solvent

“…41 Ketene aminals were synthesized according to literature. 21,42 Briey, 1,1bis(methylthio)-2-nitroethylene (1 mmol) and diamines (1 mmol) or primary amines (2 mmol) have been reacted in EtOH at reux for 2-4 h. The precipitate has been ltered and washed by cold ethanol (82-95% yield) (Table 3).…”

NitroketeneN,S-acetals: synergistic building blocks for the synthesis of heterocycles

“…35 Again, similar conditions were utilized for the synthesis of the cyclic and acyclic nitroketene N,S-acetals 23 and 25 by the same group (Scheme 7). 36 Dunkern et al described a slightly modied protocol for the synthesis of the nitroketene N,S-acetal derivatives 28 from 15, as depicted in Scheme 8. 37 The precursor 15 was prepared by mixing 26 with MeI in DMF at room temperature.…”

Microwave Assisted Reactions of Azaheterocycles Formedicinal Chemistry Applications

“…While using MW irradiation, Sangi et al [31] obtained several imidazolidines, oxazolidines, and benzoxazoles. As key intermediate in these reactions, they use 1,1-bis(thiomethyl)-2-nitroethylene 33, that treated with various alkyldiamines, hydroxylalkylamines, or hydroxylarylamines was leading to the desired compounds (34,35a-e,36) in good yields and reduced reaction time (20 min).…”