Physicochemical Properties of Lecithin-Based Nanoemulsions Obtained by Spontaneous Emulsification or High-Pressure Homogenization

Schuh, Roselena Silvestri; Bruxel, Fernanda; Teixeira, Hélder Ferreira

doi:10.5935/0100-4042.20140186

Cited by 34 publications

(39 citation statements)

References 3 publications

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“…Where: rate of flow is signified by (D) and applied stress is denoted by (τ) (Schuh et al 2014). Via drawing shear rate versus shear stress, It was found that all NEs viscosity obtained were of Newtonian flow behavior (Fig.…”

Section: Viscosity Determination Filter Paper Test Dye Miscibility mentioning

confidence: 99%

Oral nanoemulsions of candesartan cilexetil: formulation, characterization and in vitro drug release studies

Ali

Hussein

2017

AAPS Open

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Nanoemulsion is considered to be a new and exciting field of research that seeks to exploit the attractive properties of components to improve oral delivery of drugs like candesartan cilexetil used in the management of chronic diseases. Candesartan cilexetil is a lipophilic acidic drug with a half-life of about (5-10) hour and absolute bioavailability of (14-40%). For this reason, the study target was to formulate and characterize candesartan cilexetil nanoemulsions that could improve solubility, dissolution and stability of the lipophilic drug candesartan cilexetil. The solubility of candesartan cilexetil was checked in various vehicles in order to choose the best solubilizing components for building up an efficient nanoemulsion based on regulating hydrophilic/lipophilic balance (HLB) value above 10, and then pseudo-ternary phase diagram was used as a useful tool to evaluate the nanoemulsion domain. The nanoemulsion formulations were prepared using various concentrations of cinnamon oil, tween 80 with poloxamer mixture and transcutol HP as oil, surfactant mixture and co-surfactant respectively by aqueous titration method at surfactant/co-surfactant ratios of 3:1 and 4:1 and varying the type of poloxamer in each ratio. The prepared nanoemulsions were tested for nanodispersion stability studies, droplet size distribution, polydispersity index, zeta potential, viscosity, filter paper spreadability, dye miscibility, electroconductivity, pH, percent transmittance, surface tension, refractive index, morphology and drug dissolution. It was found that release rate and extent for all prepared nanoformulations were significantly higher (p < 0.05) than marketed tablet formulation as well as plain drug powder. The results demonstrated that, the potential use of this system is a perfect technique for improving solubility and dissolution of candesartan cilexetil.

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Section: Viscosity Determination Filter Paper Test Dye Miscibility mentioning

confidence: 99%

Oral nanoemulsions of candesartan cilexetil: formulation, characterization and in vitro drug release studies

Ali

Hussein

2017

AAPS Open

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“…In the nanoemulsion gel, the globule size increased to a greater extent than in the nanoemulsion, which led to the nanoemulsion gel becoming less stable than the nanoemulsion. The pH value reduction indicated by the stability test could result in a decrease in the zeta potential (i.e., it could become less negative) and an increase in the speed of flocculation [15].…”

Section: Discussionmentioning

confidence: 99%

Physical Stability and Antioxidant Activity Assay of a Nanoemulsion Gel Formulation Containing Tocotrienol

Suminar

Jufri

2017

Int J App Pharm

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Objective: Tocotrienols have an antioxidant potential higher than that of tocopherols. Nanoemulsion gel can deliver tocotrienols into the skin to prevent skin damage caused by free radicals and improve the stability of the dosage form. The present study aimed to determine the physical stability and antioxidant activity of a nanoemulsion gel formulation containing tocotrienol. Methods:The tocotrienol nanoemulsion was made using tocotrienols, oleic acid, Tween 80, 96% ethanol, and propylene glycol. The gel base was made using a carbomer and triethanolamine. A physical stability test was conducted at three different temperatures, namely, low temperature (4±2°C), room temperature (27±2°C), and high temperature (40±2°C). The antioxidant activity was measured using the 2,2-diphenyl-1-picrylhydrazyl method for determining inhibitory concentration (IC 50 ) values.Results: Formula 1 demonstrated the best physical stability, with a pH of 6.2. The droplet size of the tocotrienol nanoemulsion gel was 596 nm, with a zeta potential value of −27.1 nm. The IC 50 of the tocotrienol nanoemulsion gel was 6252.14 ppm. Conclusion:The nanoemulsion gel formulation retained antioxidant activity and was physically stable for 8 weeks.

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“…Smaller quantities of acidic lipids may also be present. They are ionized at pH 7.0 and induce a negative surface change on NE droplets [40], and this may be related to the low electrostatic repulsion of the formulations containing Tween 60. In addition, neutral pH minimizes lecithin hydrolysis [41].…”

Section: Page 11 Of 22mentioning

confidence: 99%

Development and characterization of Pterodon pubescens oil nanoemulsions as a possible delivery system for the treatment of rheumatoid arthritis

Hoscheid

Outuki

Kleinubing

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Physicochemical Properties of Lecithin-Based Nanoemulsions Obtained by Spontaneous Emulsification or High-Pressure Homogenization

Cited by 34 publications

References 3 publications

Oral nanoemulsions of candesartan cilexetil: formulation, characterization and in vitro drug release studies

Oral nanoemulsions of candesartan cilexetil: formulation, characterization and in vitro drug release studies

Physical Stability and Antioxidant Activity Assay of a Nanoemulsion Gel Formulation Containing Tocotrienol

Development and characterization of Pterodon pubescens oil nanoemulsions as a possible delivery system for the treatment of rheumatoid arthritis

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