Application of the WINROP model in Retinopathy of Prematurity (ROP) screening in a
            Portuguese cohort of premature infants

Malheiro, Luísa; Falcão, Inês; Neiva, Luísa; Almeida, Alexandra; Maia, Sofia; Miranda, Vasco; Parreira, Ricardo; Menéres, Pedro

doi:10.5935/0034-7280.20190007

Cited by 3 publications

(6 citation statements)

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“…The 2018 result is far from the data presented by countries from various regions of Europe. It is only surpassed by the results from Portugal, in which the percentage of ROP diagnoses in the 2010-2016 period reached 64.1% [18], and 42.3% in 2008-2019 [17], Norway in 2009-2017 (39.6%) [20], and a single center in Florence, Italy (38%) in 2017-2020 [15]. These results are also matched by those of a Swedish study in 2008-2017 (31.9%) and in 2008-2015 (31.9%) [22,24].…”

Section: Discussionmentioning

confidence: 75%

“…The data contains the number of preterm infants screened and those with an already established diagnosis of ROP, but there are no other demographic characteristics or parameters related to prematurity that fully define the characteristics of the groups of preterm infants studied. Epidemiological studies in Europe are conducted by individual bodies, as in France [11], Greece [12,13], Italy [14,15], Portugal [16][17][18], or multiple institutions, as in the Netherlands (80 centers) [6,19], Norway (Norwegian Neonatal Network, NNN) [20], Switzerland (SwissNeoNet registry) [21], or Sweden (SWEDROP register) [22][23][24]. Some articles contain the data of both individual and multiple centers.…”

Section: Resultsmentioning

confidence: 99%

“…Figueiredo et al [17] Malheiro et al [18] Switzerland Gerull et al [21] No uniform screening criteria. The criteria was differed slightly between the individual centers.…”

Section: Polandmentioning

confidence: 99%

“…The mean BW and GA were, respectively, 1241.6 g (±310) and 29.8 (±3.4) weeks. Next is a study by Malheiro et al [18], conducted between 2010 and 2016 at the Centro Hospitalar Universitário do Porto, on a group of 496 preterm infants undergoing screening, among whom ROP was diagnosed in 64.1% (275 out of 496), while only 5.8% of the preterm infants (26 out of 496) required treatment. A total of 92.3% of the newborns (24 out of 26) received diode laser treatment, while 7.7% (2 out of 26) underwent cryoablation.…”

Section: Portugalmentioning

confidence: 99%

See 3 more Smart Citations

Most Up-to-Date Analysis of Epidemiological Data on the Screening Guidelines and Incidence of Retinopathy of Prematurity in Europe—A Literature Review

Modrzejewska

Bosy-Gąsior

2023

JCM

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Introduction: Global predictions indicate that the incidence of retinopathy of prematurity (ROP) is increasing, but the lack of current epidemiological data on the occurrence of ROP in Europe prompted the authors to update these data. Methods: European studies related to the presence of ROP were analyzed, and the reason for the differences in the percentage of ROP and different screening criteria were checked. Results: The study presents results from individual and multiple centers. Current ROP incidence data varies from a low of 9.3% in Switzerland to the highest values of 64.1% in Portugal and 39.5% in Norway. The national screening criteria are used in the Netherlands, Germany, Norway, Poland, Portugal, Switzerland, and Sweden. Uniform criteria—Royal College of Paediatrics and Child Health guidelines are used in England and Greece. American Academy of Pediatrics screening guidelines are used in France and Italy. Conclusions: The epidemiology of ROP in European countries varies significantly. The increase in the diagnosis and treatment rate of ROP in recent years correlates with the narrowing of diagnostic criteria in newly issued guidelines (which include the WINROP and G-ROP algorithms), a higher number of less developed preterm infants, and a lower percentage of live births.

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Section: Discussionmentioning

confidence: 75%

Section: Resultsmentioning

confidence: 99%

“…Figueiredo et al [17] Malheiro et al [18] Switzerland Gerull et al [21] No uniform screening criteria. The criteria was differed slightly between the individual centers.…”

Section: Polandmentioning

confidence: 99%

Section: Portugalmentioning

confidence: 99%

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Most Up-to-Date Analysis of Epidemiological Data on the Screening Guidelines and Incidence of Retinopathy of Prematurity in Europe—A Literature Review

Modrzejewska

Bosy-Gąsior

2023

JCM

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“…The more immature the infant, the harder it is to achieve adequate growth. The problem encountered by neonatologists all over the world is reflected in the high number of false positives reported in WINROP validation studies [16][17][18][19]34,[50][51][52][53][54] . Some suggest it may be due to difference in the expected growth of their population 46 .…”

Section: Discussionmentioning

confidence: 99%

Assessment of Neonatal Care Standard by the Predictive Model for Retinopathy of Prematurity Based on Weight Gain

Čolić

2023

ACC

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Care of extremely premature infants is in constant need for evaluation and progress. WINROP, a predictive model based on weight gain, has been developed to reduce the number of stressful examinations for retinopathy for prematurity. Validation studies of WINROP emphasize the difference of applicability in neonatal units of various practice. The aim of the study was to assess the standard of neonatal care by WINROP. Data on extremely premature infants were collected from medical records and entered in WINROP. High-and low-risk WINROP distribution and retinopathy of prematurity outcomes were analyzed. Fifty-four infants, gestational age ≤28 weeks, were included in the study after exclusion of weight related comorbidities. High risk was noted in 74% (n=40) of infants with 24% (n=13) developing retinopathy of prematurity requiring treatment. In low alarm group, there were 3 cases with severe disease. In conclusion, WINROP is not just a provider of predictive information on the severity of retinopathy of prematurity. High-risk alarm indicates the need of adjustment of nutritional strategies. Infants without pathological growth morbidities who develop severe retinopathy of prematurity in low-risk group point to other risk factors for retinopathy of prematurity to be evaluated and changed in future practice.

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The Effects of Combuxil and Leizumab on Retinal Function and Serum Interleukin-17A in Premature Infants with Retinopathy

Ren

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To investigate the effects of Compaximab and raizumab on retinal function and serum interleukin-17A level in retinopathy of prematurity. Methods. Sixty cases of retinopathy of prematurity treated in our hospital from February 2019 to April 2021 were selected. The patients were randomly divided into control group ( n = 30 ) and research group ( n = 30 ). The control group was treated with Compaq and the research group was treated with razumab. The curative effect, retinal function, incidence of complications, intraocular pressure at different time, and the level of serum interleukin-17A were compared. Results. Compared with the two groups, the curative effect of the research group 93.33% (28/30) was greater than that of the control group 66.67% (20/30), and the difference was statistically significant ( P < 0.05 ). Compared with the incidence of complications, the incidence of corneal opacity, lens opacity, preretinal and vitreous hemorrhage, endophthalmitis, and traction retinal detachment in the research group was greatly lower, and the difference was statistically significant ( P < 0.05 ). Following the therapy, the IOP of the two groups decreased at different times. The IOP of 1 min, 10 min, and 30 min in the research group was obviously lower, and the difference was statistically significant ( P < 0.05 ). Following treatments, the levels of serum IL-17A were decreased. Compared with the control group, the level of serum IL-17A in the research group was greatly downregulated, and the difference was statistically significant ( P < 0.05 ). Conclusion. Intravitreal injection of razumab is an effective treatment for retinopathy of prematurity, which can effectively improve the retinal function of infants. The level of serum interleukin-17A can be reduced and intraocular pressure can be regulated, which is safe and effective.

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Application of the WINROP model in Retinopathy of Prematurity (ROP) screening in a Portuguese cohort of premature infants

Cited by 3 publications

References 0 publications

Most Up-to-Date Analysis of Epidemiological Data on the Screening Guidelines and Incidence of Retinopathy of Prematurity in Europe—A Literature Review

Most Up-to-Date Analysis of Epidemiological Data on the Screening Guidelines and Incidence of Retinopathy of Prematurity in Europe—A Literature Review

Assessment of Neonatal Care Standard by the Predictive Model for Retinopathy of Prematurity Based on Weight Gain

The Effects of Combuxil and Leizumab on Retinal Function and Serum Interleukin-17A in Premature Infants with Retinopathy

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