Optical coherence tomography angiography findings in patients with ocular and non-ocular Behcet disease

Topçu-Yılmaz, Pınar; Özdemir, Emre; Numan, Mehmet

doi:10.5935/0004-2749.20210031

Cited by 4 publications

(2 citation statements)

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“… Methodological item for non-randomized studies (No. 1–8) Goker et al 16 Çömez et al 17 Türkcü et al 18 Karalezli et al 19 Emre et al 20 Accorinti et al 28 Koca et al 29 Aksoy et al 30 Eser-Ozturk et al 31 Smid et al 32 Cheng et al 33 Yilmaz et al 34 Pei et al 35 1. Is the Case Definition Adequate?…”

Section: Resultsmentioning

confidence: 99%

“…Another important explanation may be the relatively small number of eyes in the two groups. Moreover, differences in disease duration and patient characteristics may contribute to this discrepancy 34 . Our results are consistent with those of several studies that revealed a significant reduction in VD in the macular whole enface superficial and deep layers, foveal superficial and deep layers, and parafoveal superficial and deep layers in eyes with non-ocular BD 16 , 17 , 32 .…”

Section: Discussionmentioning

confidence: 99%

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Retinal microvasculature features in patients with Behcet’s disease: a systematic review and meta-analysis

Mei

et al. 2022

Sci Rep

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This meta-analysis aimed to analyze retinal microvasculature features in eyes with Behçet’s disease (BD) using optical coherence tomography angiography (OCTA). Electronic databases, including PubMed, Web of Science, Embase, and Cochrane Library, were comprehensively searched for published studies comparing retinal microvasculature characteristics between eyes with BD and controls. Continuous variables were calculated using the mean difference (MD) with 95% confidence interval (CI). Review Manager software (version 5.30) was used to conduct statistical analysis. A total of 13 eligible studies involving 599 eyes with BD and 622 control eyes were included in the meta-analysis. The pooled results showed that the macular whole enface superficial and deep vessel density (VD) values measured by OCTA were significantly lower in eyes with BD than in control eyes (superficial VD: MD = − 3.05, P < 0.00001; deep VD: MD = − 4.05, P = 0.0004). The foveal superficial and deep VD values were also significantly lower in the BD group than in the control group (superficial VD: MD = − 1.50, P = 0.009; deep VD: MD = − 4.25, − = 0.03). Similarly, the analysis revealed a significant reduction in the parafoveal superficial and deep VD in eyes with BD than in control eyes (superficial VD: MD = − 3.68, P < 0.00001; deep VD: MD = − 4.95, P = 0.0007). In addition, the superficial and deep foveal avascular zones (FAZs) were significantly larger in patients with BD than in controls (superficial FAZ: MD = 0.06, P = 0.02; deep FAZ: MD = 0.12, P = 0.03). The present meta-analysis found that macular whole enface VD, foveal VD, and parafoveal VD were lower in eyes with BD, and the FAZ was larger in patients with BD. The findings suggest that OCTA can assist clinicians in diagnosing and monitoring the status of patients with BD.

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