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Cited by 7 publications
(4 citation statements)
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“…54,70,71 Other reported dietary modifications that could also be of benefit include supplementation with proline and lysine. 7,54 Treatment modalities for cystoid macular oedema or intraretinal cystic spaces associated with GA includes the restriction of arginine in diet, 72 supplementation with vitamin B6, 72 administration of topical or oral carbonic anhydrase inhibitors, 73,74 topical non-steroidal antiinflammatory drops, 73,74 and intravitreal or subtenon steroid injections which, however, may increase the risk of cataract formation and elevation of the intraocular pressure. 28,30,75,76 Other treatment options also include injection of intravitreal anti-vascular endothelial growth factor agents, 6,57 which was shown to improve macular sensitivity and vascularity.…”
Section: Treatmentmentioning
confidence: 99%
“…54,70,71 Other reported dietary modifications that could also be of benefit include supplementation with proline and lysine. 7,54 Treatment modalities for cystoid macular oedema or intraretinal cystic spaces associated with GA includes the restriction of arginine in diet, 72 supplementation with vitamin B6, 72 administration of topical or oral carbonic anhydrase inhibitors, 73,74 topical non-steroidal antiinflammatory drops, 73,74 and intravitreal or subtenon steroid injections which, however, may increase the risk of cataract formation and elevation of the intraocular pressure. 28,30,75,76 Other treatment options also include injection of intravitreal anti-vascular endothelial growth factor agents, 6,57 which was shown to improve macular sensitivity and vascularity.…”
Section: Treatmentmentioning
confidence: 99%
“…Several interventions have been reported for the treatment of GA-associated ICS including the use of arginine-restricted diets, vitamin B6 supplementation, IVB, CAIs, and NSAIDs. 48 Importantly, all these modalities were used in our patient, but only prolonged dietary modifications gave consistent results. Previously, Kaiser-Kupfer et al studied a group of 27 patients with gyrate atrophy; of these, 17 (mean age = 13.9 years) followed an arginine-restricted diet and 10 (mean age 14.1) were unable to do so.…”
Section: Discussionmentioning
confidence: 66%
“…2 Thorough imaging studies have demonstrated that intraretinal cystic spaces (ICS) is a common finding in patients with GA and contributes significantly to vision loss and disturbance. 3 Treatment modalities for GA-associated ICS documented in the medical literature include dietary modifications such as arginine-restricted diets, 4 vitamin B6 supplementation, 5 or a combination of both, 6 and intravitreal bevacizumab injections (IVB), 7 carbonic anhydrase inhibitors (CAIs), 8 and non-steroidal anti-inflammatory drugs (NSAIDs). 8 Herein, we report a patient with GA-associated ICS who poorly responded to CAIs, NSAIDs, and repeated IVB but favorably responded to prolonged dietary modifications.…”
Section: Introductionmentioning
confidence: 99%
“…High dose vitamin B6 is also recommended in order to prevent and treat macular complications [6,7]. Additional approaches also have been used to treat the macular edema in GA, including carbonic anhydrase inhibitors (CAI) [12,13], topical non-steroid anti-in ammatory drugs [12,13], and intravitreal or periocular corticosteroid [14] or vascular endothelial growth factor antagonists [15], either separately or in combination. However, results using these other agents have shown variable and transient e cacy depending on the stage of the disease, with a better response seen in early stages of the disease and little response in advanced stages.…”
Section: Discussionmentioning
confidence: 99%