Comparison of choroidal thickness in patients with active and stable thyroid eye disease

Abstract

To compare the choroidal thickness in active and stable phases of thyroid eye disease. Methods: Forty-seven eyes of 47 patients with thyroid eye disease were prospectively studied. Patients were evaluated on the basis of their clinical activity scores, with scores ≥3 defined as active disease. Subfoveal, temporal macular, nasal macular, temporal peripapillary, and nasal peripapillary choroidal thickness measurements were performed with Cirrus enhanced depth imaging spectral-domain optical coherence tomography, and the results in the two groups were compared. Results: Twenty-four patients were int he active group, whereas 23 patients were in the stable group. Choroidal thickness was significantly higher in the subfoveal and temporal macular regions in the active group. Although the nasal macular and peripapillary values were also higher in the active group, the difference was insignificant. Conclusions: Subfoveal choroidal thickness was significantly higher in patients with thyroid eye disease in the active phase than in those with stable phase disease.

Evaluation of the Effect of Proptosis on Choroidal Thickness in Graves’ Ophthalmopathy

“…In a very recent study, subfoveal and temporal choroidal thickness values were significantly higher in the active ophthalmopathy group than in the stable group. 21 The authors attributed the higher choroidal thickness in the active group to increased intraorbital pressure leading to impaired venous drainage and inflammation. They did not report a correlation between choroidal thickness and CAS due to the small number of patients and the lack of equal distribution of activity scores.…”

“…They did not report a correlation between choroidal thickness and CAS due to the small number of patients and the lack of equal distribution of activity scores. 21 …”

Choroidal Thickness Profile in Chorioretinal Diseases: Beyond the Macula

“…This highly vascularized nature of the choroid, which can be assessed by non-invasive imaging, has drawn attention to the choroid in a variety of systemic diseases, such as the metabolic, inflammatory, and the systemic vascular disease ( 88 ). Peripapillary CT measurements have also been attempted in patients with systemic illnesses ( 24 , 89 – 93 ) such as diabetes ( 23 , 94 – 97 ), thyroid diseases ( 98 , 99 ), and pulmonary diseases ( 25 , 100 ) ( Table 3 ). Yazgan et al ( 94 ) showed that the macular and peripapillary choroid was significantly thicker in pre-diabetic patients than in healthy controls at all 15 measuring points.…”

“…The association between thyroid eye diseases and changes in the choroid has been studied with respect to autoimmune inflammatory disease. Gul et al ( 98 ) measured macular and peripapillary CT in patients with thyroid eye diseases associated with Graves' disease, nodular goiter, and Hashimoto's thyroiditis and found that the subfoveal choroid was thicker in patients with active thyroid eye disease than in those with a stable state. Peripapillary CT tended to be higher in the active group, however, the difference was not statistically significant.…”

Effects of Thyroid-stimulating Hormone Receptor Autoantibody on Retinal and Choroidal Vessels in Thyroid Eye Disease

“…이는 TSHR Ab가 증가할수록 sFAZ, dFAZ 크기가 작아지 는 경향성을 보인다는 것인데, 1.5 IU/L 이상만 포함했던 Gul et al31 의 결과는 Özkan et al 32 이 활동기 의 갑상샘눈병증에서 맥락막이 의미 있게 두꺼워진다고 보 고한 결과와 같았다. 또 다른 참고 논문에서는 아시아인의 안와는 타 인종보다 안와벽이 두껍고 좁아 안와후부의 부 종의 직접적인 영향으로 CT가 감소할 수 있다는 보고도 있 었다.…”