Corneal properties and glaucoma: a review of the literature and
            meta-analysis

Gaspar, Ricardo de Oliveira; Pinto, Luís Abegão; Sousa, David Cordeiro

doi:10.5935/0004-2749.20170050

Cited by 20 publications

(25 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As shown in other publications, in our study, both CH and CRF values were lower in POAG patients than in OH patients and in NE [ 10 , 24 , 25 , 30 , 31 , 33 , 36 – 40 ], and a study that included both eyes of POAG patients revealed that the most affected eye had a lower CH compared to the other eye [ 16 ]. Moreover, studies revealed that a high CH has a protective role in OH patients [ 38 ].…”

Section: Discussionsupporting

confidence: 87%

“…Our study revealed that means of GCC thickness were higher in NE than in OH eyes and higher than in POAG patients. Other studies also proved that in glaucoma patients, means of GCC correspond to means of pRNFL and are lower than in normal individuals [ 10 , 18 , 38 , 41 ].…”

Section: Discussionmentioning

confidence: 90%

“…Studies have found a statistically significant change in preperimetric glaucoma in patients compared to normal subjects, and that GCC scan gives similar results to pRNFL scan in patients with preperimetric glaucoma [ 10 , 33 ]. Since the cornea and sclera have a common histological base, corneal biomechanics could be linked to laminar changes in glaucoma patients.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Relationship Between Corneal Hysteresis and Retinal Ganglion Cells – A Step Forward in Early Glaucoma Diagnosis

et al. 2020

View full text Add to dashboard Cite

Background Glaucoma is a major cause of irreversible visual field (VF) loss across the world. Many studies have assessed the accuracy of glaucoma diagnostic tests for a more precise diagnosis to quickly identify patients with higher risk of progression. Material/Methods We conducted a study that included 214 eyes divided into 3 groups: 79 eyes from patients diagnosed with primary open-angle glaucoma (POAG), 68 eyes from patients diagnosed with ocular hypertension (OH), and 67 eyes from normal individuals (normal eyes, NE). All patients included in the study received a complete checkup. Results In POAG patients, means of central corneal thickness (CCT), corneal hysteresis (CH), corneal resistance factor (CRF), mean defect (MD), visual field index (VFI), peripapillary retinal nerve fiber layer (pRNFL), and ganglion cell complex (GCC) are lower than in OH patients, and in NE are higher than in both groups. Also, we found a statistically significant direct correlation between CH and GCC thickness. Further statistical analysis revealed that both pRNFL thickness and GCC thickness are significantly influenced by CH value in a precise manner. Conclusions The first cell type affected in glaucoma is the retinal ganglion cell. We found a positive correlation between GCC thickness and CH, suggesting that CH might be a parameter to consider in the evaluation of all glaucoma patients from their first examination. Moreover, both pRNFL thickness and GCC thickness are influenced by CH, suggesting the utility of monitoring the value of CH at every checkup to detect its decrease in glaucoma patients.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Relationship Between Corneal Hysteresis and Retinal Ganglion Cells – A Step Forward in Early Glaucoma Diagnosis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In fact, important correlations between corneal pachymetry and glaucoma have emerged unequivocally, due to the diffusion of refractive surgery and the related pre-op tests. Considering that the CCT in normal conditions is just over half a millimeter (540 ± micron), patients with thin cornea have a higher risk of development and progression of glaucomatous damage, while those with thick cornea are more protected from glaucomatous risk ( Figure 6) (Gaspar et al, 2017;Belovay and Goldberg, 2018). However, it is important to remember that measurement of IOP by standard techniques is lower than the real value in patients with thin cornea and higher in those with thick cornea.…”

Section: Glaucoma Diagnosismentioning

confidence: 99%

The Hub-and-Spoke Management of Glaucoma

Nuzzi

2020

Front. Neurosci.

View full text Add to dashboard Cite

Glaucoma is an extremely significant public health issue, since it is the most common cause of irreversible blindness worldwide, nevertheless it is still widely undiagnosed because of its devious nature. Glaucoma diagnosis criteria are well-defined and have to be strictly observed and recognized: the earlier the disease is diagnosed, the earlier the patient can undergo the most suitable treatment, the better can be the prognosis. The three levels of prevention are essential in the approach to the disease and its pathophysiological features make it eligible for screening. This review provides an overview of the current state of the art in glaucoma management, starting from its prevention and coming to the hub-and-spoke organization. This model applied to glaucoma aims to direct patients toward professional and not professional figures who may guide them in integrated care pathway. This path should be designed in accordance with best practice to coordinate glaucoma prevention, diagnosis, treatment and follow up with the best cost-benefit ratio, protecting both the interests of the patient and of the society.

show abstract

“…ст., 95 % ДИ [-1,68, -1,41], p < 0,0001) отмечено в результате обобщенного анализа R. Gaspar и соавт. [28]. В этом же исследовании ЦТР была значительно ниже в группе глаукомы, чем в контрольной группе (MD = -8,49 мкм, 95 % ДИ [-11,36, -5,62], p < 0,001).…”

unclassified

Advantages of dynamic bi-directional applanation tonometry in primary open-angle glaucoma diagnostics

Загидуллина

Азнабаев

Лакман

et al. 2019

Rossijskij oftalʹmologičeskij žurnal

View full text Add to dashboard Cite

Purpose. To study tonometry parameters features, measured by different methods, taking into account individual morphometric eye parameters and biomechanical properties of the corneoscleral shell in patients with the initial and the advanced stages of primary open angle glaucoma (POAG).Material and methods. 51 patients (99 eyes) aged 48–82, with the initial (45 eyes) and advanced stages (54 eyes) of POAG were examined. The control group consisted of 31 patients (62 eyes) aged 47–83 without ophthalmic pathology. In addition to standard ophthalmologic examination, tonometry was performed using the Ocular Response Analyzer (ORA, Reichert Inc., the USA).Results. The main tonometry parameters of ORA revealed significant differences between POAG patients and the control group. No significant difference in the central corneal thickness (CCT) was found between the POAG and the control group. Patients with I and II stages of glaucoma taken separately showed differences in CCT and tonometry parameters.Conclusion. Dynamic bi-directional applanation tonometry enables to take into account the changes in viscoelastic properties of the corneoscleral eye shell, and definitely has diagnostic advantages in examining patients with various stages of POAG.

show abstract

Corneal properties and glaucoma: a review of the literature and meta-analysis

Abstract: Corneal properties appear to differ between glaucoma patients and healthy controls. Our results emphasize the importance of corneal biomechanical properties in IOP interpretation and should support further studies on the influence of CH and CCT in glaucoma screening and diagnosis.

Cited by 20 publications

References 0 publications

The Relationship Between Corneal Hysteresis and Retinal Ganglion Cells – A Step Forward in Early Glaucoma Diagnosis

The Relationship Between Corneal Hysteresis and Retinal Ganglion Cells – A Step Forward in Early Glaucoma Diagnosis

The Hub-and-Spoke Management of Glaucoma

Advantages of dynamic bi-directional applanation tonometry in primary open-angle glaucoma diagnostics

Contact Info

Product

Resources

About