Safety and efcacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsifcation

Abstract

There was a 7.3-fold lower ratio of endophthalmitis in the group that received moxifloxacin intracameral injection. This study provides further evidence that moxifloxacin is an effective intracameral prophylactic antibiotic.

An Alternative Approach to Cataract Surgery Using BSS Temperature of 2.7 °C

“…Cataract surgery-despite being nowadays much more standardized and safe, and widely regarded as an ordinary practice in the ophthalmological field-still has some limitations [2]. Indeed, cataract surgery may present possible postoperative complications such as corneal decompensation [3], the possibility of a cornea with more swelling [4], anterior chamber reaction [5], cystoid macular edema [6], increased intraocular pressure, and, rarely, endophthalmitis [7]. An objective approach to preoperative evaluations is required to obtain the best results [8].…”

“…However, this is primarily due to the laser performing nuclear fragmentation and capsulorhexis, which reduces the level of energy required for nuclear fragmentation and decreases the average loss of endothelial cells to around 20% [6]. Surgical damage to the endothelium can have severe consequences on functional outcome and on the consequent recovery of the patient [7]. For this reason, for many years, technological research has been devoted to reducing this loss, for example by using fewer ultrasounds, thanks to femtosecond lasers [10][11][12][13].…”

The Anterior Chamber Injection of Moxifloxacin Injection to Prevent Endophthalmitis after Cataract Surgery: A Meta-analysis

“…A total of 2,686 articles were collected through relevant database searches and other resources, and 262 duplicates were deleted. After exclusion according to the topic, abstract, and intensive reading of the full text, 8 articles were finally included [11][12][13][14][15][16][17][18]. e literature was analyzed by Meta.…”

“…is meta-analysis included 8 studies [11][12][13][14][15][16][17][18], with 123,819 eyes; 2 studies were RCTs [11,17], 2 studies were case-control studies [12,13], and 4 studies were cohort studies [14][15][16]18]. Two studies [11,14] were conducted in Brazil, 1 study [17] was conducted in the USA, 1 study [12]was conducted in Turkey, 1 study [13] was conducted in Canada, 1 study [18] was conducted in Colombia, and 2 studies [15,16] were conducted in Japan. e follow-up time ranged from 2 weeks to 1 year.…”

“…[11,17] were RCTs, and we used the Cochrane risk of bias tool to assess these studies; the RCTquality evaluation results are shown in Figures 2 and 3. For non-RCTs [12][13][14][15][16]18], we used the Newcastle-Ottawa scoring system to evaluate the quality of the literature. e total scores were 1 to 3, 4 to 6, and 7 to 9, representing low-, medium-, and high-quality studies, respectively.…”