The outcome of penetrating keratoplasty for corneal scarring due to herpes simplex
            keratitis

Altay, Yesim; Tamer, Sema; Kaya, Abdullah; Balta, Özgür; Burcu, Ayşe; Örnek, Firdevs

doi:10.5935/0004-2749.20170011

Cited by 12 publications

(9 citation statements)

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“…Herpetic keratitis recurrence has been reported at 20% in the literature. 12 Our cases did not have any recurrence during the follow-up period.…”

Section: Discussionmentioning

confidence: 45%

Outcomes of Therapeutic and Tectonic Penetrating Keratoplasty in Eyes with Perforated Infectious Corneal Ulcer

Doğan¹,

Arslan²

2019

tjo

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Objectives: To evaluate the outcomes of penetrating keratoplasty performed for therapeutic and tectonic purposes in eyes with perforated infectious corneal ulcer. Materials and Methods: This retrospective study included 43 eyes of 43 patients who developed perforated infectious corneal ulcer of various etiological causes between June 2008 and January 2018. The patients were evaluated based on age and sex, follow-up time, presence of corneal perforation, pre- and postoperative visual acuity, postoperative graft transparency, complications, and infection recurrence. Results: The mean age of the 43 patients was 52.9±13.8 years. The mean follow-up time was 2.7±1.3 years. Preoperatively, the visual acuity of the eyes was at the level of hand motions or counting fingers; postoperative best corrected visual acuity ranged from hand motions to 0.7. Postoperative complications included hyphema in 8 patients (18.6%), elevated intraocular pressure in 14 (32.5%), posterior synechiae in 18 (41.8%), and cataract in 22 patients (51%). Therapeutic and tectonic success was achieved in 42 patients (97.6%). Postoperative graft transparency was observed in 35 patients (83.3%) within the 1-year follow-up period and in 27 patients (71.0%) at 2 years. Among 27 patients with graft transparency, 23 had bacterial and 4 had viral etiologies (p=0.52); 16 patients had perforations smaller than 1 mm and 11 had perforations 1-3 mm in size (p=0.2). Conclusion: Therapeutic-tectonic keratoplasty for perforated infectious corneal ulcer successfully restored globe integrity in 97.6% of cases. The rate of graft transparency was 71.0% at 2 years, with no effect of etiological agent or perforation size.

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“…Herpetic keratitis recurrence has been reported at 20% in the literature. 12 Our cases did not have any recurrence during the follow-up period.…”

Section: Discussionmentioning

confidence: 45%

Outcomes of Therapeutic and Tectonic Penetrating Keratoplasty in Eyes with Perforated Infectious Corneal Ulcer

Doğan¹,

Arslan²

2019

tjo

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“…In the study of Shimizu et al (23), PK and DALK procedures achieved similar improvement in VA but no data about the complications were given. PK showed graft rejection lower than 10% in the study performed by Altay et al (30) and 93% of the patients achieved BCVA better than 1.2 logMAR. Last but not least, in the comparative study of Wu et al 24, PK showed a significantly higher number of graft rejections when compared with full-bed DLK (41.3% and 0%, respectively, p < 0.05).…”

Section: Study Characteristicsmentioning

confidence: 70%

“…Regarding PK procedure, in the study of Altay et al (30), among 55 patients, recurrence of HSK was noted in 28.5%. In group 1, which included patients with quiescent herpetic corneal scar, graft failure was observed in 19%, and graft rejection in 9.52%, while in group 2, which included patients with a corneal descemetocele or perforation, graft failure was noted in 30.8% and graft rejection in 23.07% (30). According to Zheng et al (25), who performed PK and DALK with APCS in different patients, the overall recurrence rate was 23% and inflammation occurred in 7.6% of the subjects.…”

Section: Secondary Outcomesmentioning

confidence: 94%

“…In DALK using GCCTs, different complications were observed; among them, microperforation (14.8%), double anterior chamber (7.4%) and recurrence (7.4%) (26). Regarding PK procedure, in the study of Altay et al (30), among 55 patients, recurrence of HSK was noted in 28.5%. In group 1, which included patients with quiescent herpetic corneal scar, graft failure was observed in 19%, and graft rejection in 9.52%, while in group 2, which included patients with a corneal descemetocele or perforation, graft failure was noted in 30.8% and graft rejection in 23.07% (30).…”

Section: Secondary Outcomesmentioning

confidence: 99%

“…Other research teams performed: DALK using acellular corneal tissue (ACT) (32), DALK using precut anterior lamellar cap (ALC) (31), acellular porcine corneal stroma (APCS) DALK (22), or DALK using glycerol-cryopreserved corneal tissues (GCCTs) (26) ( Table 3). PK as the only intervention was carried out by Altay et al (30). Shimizu et al (23), in their comparative study, divided the participants in two groups, one in which PK was performed and another one in which DALK was applied.…”

Section: Secondary Outcomesmentioning

confidence: 99%

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Corneal Graft Success Rates in HSV Keratitis: A Systematic Review

Skarentzos

Chatzimichael

Panagiotopoulou

et al. 2020

Acta Med. (Hradec Kralove, Czech Repub.)

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Herpes Simplex Virus (HSV) has worldwide prevalence. The primary objective of this systematic review was to compare penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) regarding the efficacy and complications of the treatment of corneal scarring caused by herpes simplex keratitis. Out of the 469 articles identified during the combined search of the literature based on the PubMed and Cochrane libraries, 10 retrospective and 2 prospective studies published from January 2010 to December 2019 were included. The study outcomes indicated that both surgical approaches resulted in a comparable improvement of visual acuity (VA). However, DALK demonstrated fewer complications in the majority of studies. Higher graft survival rates were associated with higher acyclovir (ACV) doses (above 800 mg/day), topical steroid and antibiotic drops. In conclusion, in terms of postoperative VA, both PK and DALK demonstrate comparable efficacy. However, DALK, which is applied in less severe HSK cases, is associated with fewer complications and better graft survival rates. High dosages of ACV, topical steroids and antibiotics contribute significantly to improved postoperative outcomes.

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Ocular surgery after herpes simplex and herpes zoster keratitis

Kanclerz¹,

Alió

2020

Int Ophthalmol

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The outcome of penetrating keratoplasty for corneal scarring due to herpes simplex keratitis

Cited by 12 publications

References 0 publications

Outcomes of Therapeutic and Tectonic Penetrating Keratoplasty in Eyes with Perforated Infectious Corneal Ulcer

Outcomes of Therapeutic and Tectonic Penetrating Keratoplasty in Eyes with Perforated Infectious Corneal Ulcer

Corneal Graft Success Rates in HSV Keratitis: A Systematic Review

Ocular surgery after herpes simplex and herpes zoster keratitis

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