Tear osmolarity and ocular surface parameters in patients with psoriasis

Demirci, Göktuğ; Erdur, Sevil Karaman; Aydin, Rukiye; Balevi, Ali; Eliacik, Mustafa; Özsütçü, Mustafa; Ölmüşçelik, Oktay

doi:10.5935/0004-2749.20170002

Cited by 12 publications

(27 citation statements)

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“…They suggested psoriasis may effect on tear osmolarity and tear film function by inflammatory processes. 20 In a study by Santos da Cruz et al with 43 psoriasis patients and 86 controls, it was found that patients with psoriasis had a statistically higher rate of dry eye (16.28%), likely dry eye (32.56%), blepharitis (16.28%), and ocular surface disease and Rose Bengal tests were more abnormal in patients with psoriasis. 21 In the present study, according to the TFOS DEWS II criteria, 24 the frequency of DED was significantly higher in patients with psoriasis (22%), which was consistent with the literature.…”

Section: Discussionmentioning

confidence: 95%

“…Dry eye test abnormalities in patients with psoriasis have been shown in several studies. 19 , 20 , 21 Ghalamkarpour et al performed a study with 200 psoriatic patients and 100 healthy controls, it was found that the mean values of TBUT and Schirmer's tests in patients were significantly lower than the controls, and significantly higher scores of OSDI were observed among patients compared to the controls. Dry eye disease was observed more frequently in the patients than in the healthy group.…”

Section: Discussionmentioning

confidence: 99%

“… 25 A large number of cells are produced in this disease, these changes may occur in the Meibomian glands and result in the obstruction of the glands and MGD. 14 , 15 , 20 , 21 The decreased Meibomian secretions due to MGD in the psoriasis group may have resulted in increased tear evaporation. In addition, DED may have occurred due to increased tear osmolarity from inflammation in patients with psoriasis.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, dry eye test abnormalities have been detected in studies about psoriasis. 19 , 20 , 21 …”

Section: Introductionmentioning

confidence: 99%

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Evaluation of ocular psoriasis with meibography

Kemeriz

Tuğrul²,

Yaşar

2022

Anais Brasileiros de Dermatologia

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Background Previous studies has shown that dry eye test abnormalities, meibomian gland dysfunction (MGD), may occur in psoriasis. Objectives The authors aimed to evaluate the dry eye disease (DED), MGD, in psoriasis patients with meibography which is a current, objective, noninvasive method for patients with meibomian gland diseases, to investigate the relationship between disease severity and ocular involvement. Methods This study included 50 participants with psoriasis and 50 healthy individuals. All subjects were examined by the same dermatologist and referred for ophthalmological examination including meibomian gland obstruction, lid margin alterations assessment, ocular surface disease index assessment, tear film break-up time test, Schirmer test, corneal conjunctival fluorescein staining assessment. Additionally, upper and lower lids were evaluated for meibomian gland loss with meibography. Results MGD (28%), meibomian gland loss (MGL) (29.5%), upper meiboscore (0.61 ± 0.81), lower meiboscore (0.46 ± 0.61), DED (22%) were significantly higher in the psoriasis group compared with the control group (p = 0.008, p < 0.001, p = 0.027, p = 0.041, p = 0.044, respectively). There was a significant relationship between MGD and psoriasis area severity index (PASI) (p = 0.015, Odds Ratio = 1.211). There was a significant positive relationship between MGL with PASI (p < 0.001, r = 608) and psoriasis duration (p < 0.001, r = 0.547). Study limitations Smaller study group and inability to detect quality changes of meibum with meibography were limitations of the study. Conclusions Psoriasis may affect the meibomian gland morphology, may cause structural changes in meibomian glands, and as a result of these may cause MGD and DED. Therefore, ophthalmologists and dermatologists should be aware of this situation and co-evaluate the patients in this respect.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Additionally, dry eye test abnormalities have been detected in studies about psoriasis. 19 , 20 , 21 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of ocular psoriasis with meibography

Kemeriz

Tuğrul²,

Yaşar

2022

Anais Brasileiros de Dermatologia

View full text Add to dashboard Cite

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“…On the other hand, Celik et al [20] suggested that psoriasis affected the corneal biomechanical properties. Demirci et al [21] found out that osmolarity values, OSDI and Oxford scale scores were significantly higher and the tear film break-up time was significantly shorter in patients with psoriasis compared to the healthy controls. Some researchers evaluated the posterior segment structures of the eye in psoriasis, which had similar aspects with LP in the pathogenesis since it also involved systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of ocular findings in patients with lichen planus

Özlü¹,

Teberik²

2019

pdia

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Introduction Lichen planus (LP) is a chronic, inflammatory disease of unknown etiology. Aim To evaluate the tear functions and the retinal and choroidal thickness (CT) in patients with LP. Material and methods In total, 33 patients and 30 healthy controls were enrolled. All participants were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer 1 test (with anesthesia), tear break-up time (TBUT) test, intraocular pressure (IOP), axial length (AL), and central corneal thickness (CCT). The measurements of retinal thickness (RT) and CT were obtained by spectral domain optical coherence tomography. Results No significant difference was observed between the groups in IOP, AL, CCT, or RT ( p > 0.05 in each group). There was a significant difference in the Schirmer 1 test, TBUT, and OSDI questionnaire ( p < 0.05 in each group). Choroidal thickness in LP patients was thinner than that in the controls ( p = 0.001 in each location). There was a moderate negative correlation between the disease duration and Schirmer 1 test, TBUT, and subfoveal CT ( r = –0.426, r = –0.555, r = –0.637; p = 0.001, p = 0.001, p = 0.001, respectively). There was a moderate negative correlation between the oral mucosal involvement and Schirmer 1 test, TBUT, and subfoveal CT ( r = –0.345, r = –0.392, r = –0.467; p = 0.006, p = 0.001, p = 0.001, respectively). There was a positive correlation between disease duration, oral mucosal involvement and OSDI score ( r = 0.717, r = 0.345; p = 0.001, p = 0.006, respectively). Conclusions Lichen planus may influence tear function tests and may cause dry eye. Patients with LP had lower CT values than healthy controls. Further studies are needed to clarify the effect of LP on the eyes.

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