2016
DOI: 10.5935/0004-2749.20160002
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Abstract: Approved by the following research ethics committee: Altino Ventura Foundation (protocol #1.361.143) and was conducted at the Altino Ventura Foundation. ABSTRACTPurpose: In 2015, a twenty-fold increase in the prevalence of microcephaly in Brazil was reported, and the Ministry of Health associated this abnormal prevalence with the maternal-fetal Zika virus (ZIKV) transmission. Methods:We assessed the ophthalmological findings of ten mothers and their infants that had been clinically diagnosed with ZIKV-related … Show more

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Cited by 260 publications
(282 citation statements)
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“…This virus, a member of the family Flaviviridae, is transmitted by mosquito bite and is also potentially sexually transmitted (113)(114)(115)(116)(117). While historically an infection has been described as causing symptoms ranging from fever and rash to Guillain-Barre syndrome (118)(119)(120)(121)(122)(123)(124), during the most recent outbreak there was also a startling increase in the incidence of fetal brain and CNS abnormalities when mothers acquired the virus during pregnancy (32,(125)(126)(127)(128)(129)(130)(131)(132)(133)(134). A causal link between ZIKV and these defects was established when the ZIKV genome was identified in the amniotic fluid of women whose fetuses had microcephaly detected during fetal ultrasound (125-127, 132, 133, 135).…”
Section: Zikv and Pregnancymentioning
confidence: 99%
“…This virus, a member of the family Flaviviridae, is transmitted by mosquito bite and is also potentially sexually transmitted (113)(114)(115)(116)(117). While historically an infection has been described as causing symptoms ranging from fever and rash to Guillain-Barre syndrome (118)(119)(120)(121)(122)(123)(124), during the most recent outbreak there was also a startling increase in the incidence of fetal brain and CNS abnormalities when mothers acquired the virus during pregnancy (32,(125)(126)(127)(128)(129)(130)(131)(132)(133)(134). A causal link between ZIKV and these defects was established when the ZIKV genome was identified in the amniotic fluid of women whose fetuses had microcephaly detected during fetal ultrasound (125-127, 132, 133, 135).…”
Section: Zikv and Pregnancymentioning
confidence: 99%
“…Ocular lesions have been observed in 34.5% of microcephalic newborns (71) and can be extensive, with macular atrophy, optical nerve alterations, optic disc hypoplasia, gross macular pigment mottling, and juxtafoveal chorioretinal atrophic lesions (71) (72) . Most of the reports, however, have been published at the beginning of the Brazilian outbreak and additional detailed studies are needed to establish a link between Zika virus and ocular lesions.…”
Section: Zika Virus and Microcephalymentioning
confidence: 99%
“…Conclusão: Os portadores de microcefalia associada ao ZIKAV apresentam atraso no desenvolvimento neuropsicomotor,alterações visuais, auditivas e sensoriais, impactando na independência funcional e na inserção social dessa população. Pode-se dizer que a aquisição de marcos de desenvolvimento pelas crianças depende do funcionamento do SNC e de outras dimensões do funcionamento orgânico, bem como da carga e da qualidade dos estímulos e das relações que a criança vivencia 1 .…”
Section: Resumo | Introdução: O Virús Zika (Zikav) No Brasilunclassified