Successful treatment of ligneous conjunctivitis with topical fresh frozen plasma in an infant

Tunay, Zühal Özen; Özdemir, Özdemir; Acar, Damla Ergintürk; gül, Ece; Akbay, Serap

doi:10.5935/0004-2749.20150083

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Blood derived therapies such as autologous serum (AS), fresh frozen plasma, human albumin and platelet-rich in growth factor (PRGF) eye drops have shown effectiveness in reducing the discomfort and ocular signs associated with ocular surface conditions, including GVHD. [140][141][142][143][144][145][146] These agents are not typically used as first-line therapies but are reserved for patients that have a recalcitrant disease, such as persistent epithelial defects. They typically are compounded, are non-preserved and are generally not covered by insurance, all reasons which limit access to many patients.…”

Section: E16mentioning

confidence: 99%

Chronic Ocular Graft Versus Host Disease: An Update and Review

Groth

Conto

Pasquini

2020

JDED

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An updated comprehensive literature review was completed of chronic ocular graft versus host disease (oGVHD) to identify current and future considerations as to the causes, diagnosis, and treatment of this complication after allogenic hematopoietic cell transplantation (HCT). Graft-versus-host disease involves multiple organ systems, including the eye, and is a leading cause of mortality and morbidity in these patients. This review consisted a comprehensive search of the PubMed, ClinicalTrials.gov and NIH.gov databases. oGVHD is a debilitating and potentially sight threatening condition. Commonly involved ocular structures include the cornea, conjunctiva, meibomian glands, eyelids, lacrimal gland and tear film. Identifying and treating the ocular complications at the early stages may improve final outcomes and quality of life in these patients. Aggressive lubrication, preservation of tear film and inflammation control, including minimizing surface scarring, are treatment goals. Co-management with HCT and other pertinent health care providers is critical for early diagnosis and to initiate prompt therapy to minimize the ocular damage. Stepped therapy, including the use of emerging systemic treatments can be useful in the management of oGVHD with stable visual function, quality of life and complication management as goals of treatment.

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Section: E16mentioning

confidence: 99%

Chronic Ocular Graft Versus Host Disease: An Update and Review

Groth

Conto

Pasquini

2020

JDED

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Combined medical and surgical approach in the management of ligneous conjunctivitis in a pediatric patient: A case report

Ahmad,

Alhamdan,

Sadiq

2023

International Journal of Surgery Case Reports

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Anterior Segment Surgeries Under Topical Fresh Frozen Plasma Treatment in Ligneous Conjunctivitis

Özbek-Uzman

Yalnız-Akkaya

Tabakçı

et al. 2020

Cornea

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Purpose: To evaluate the efficacy of topical fresh frozen plasma (FFP) therapy on clinical symptoms, findings, and prognosis after anterior segment surgeries in patients with ligneous conjunctivitis (LC). Methods: Retrospective case note review. Results: Eleven eyes of 7 cases whose remission was not achieved after medical treatment such as topical corticosteroids, cyclosporine A, and heparin were included in the study. The median age of admission was 19 (1–49) years, median duration of FFP treatment was 48 (15–79) months, median follow-up period was 62 (16–114) months, and median age at symptom onset was 12 (4–252) months. Diagnosis was made according to clinical presentations, plasminogen activities, and response to treatment. Topical FFP that was prepared in our clinic was used in all cases. Surgeries (membrane excision, eyelid surgery, deep anterior lamellar keratoplasty, and cataract surgery) were performed after at least 1 month of FFP treatment. Prosthetic contact lens was applied to one eye. During the follow-up period, recurrences requiring membrane excision and side effects from topical FFP were not observed. Conclusions: LC is a rare membranous conjunctivitis that proceeds with remissions and recurrences. When it was shown that the etiology of LC is plasminogen deficiency, FFP became the only treatment option targeting the etiology. In this study, we observed that the topical FFP is an effective treatment method that prevents recurrence and ensures regression of membranes and safer anterior segment surgeries in LC.

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Successful treatment of ligneous conjunctivitis with topical fresh frozen plasma in an infant

Cited by 4 publications

References 10 publications

Chronic Ocular Graft Versus Host Disease: An Update and Review

Chronic Ocular Graft Versus Host Disease: An Update and Review

Combined medical and surgical approach in the management of ligneous conjunctivitis in a pediatric patient: A case report

Anterior Segment Surgeries Under Topical Fresh Frozen Plasma Treatment in Ligneous Conjunctivitis

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