2015
DOI: 10.5935/0004-2749.20150041
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Purpose: In the lacrimal gland (LG) acinar cells, signaling regulates the release of secretory vesicles through specific Rab and SNARE exocytotic proteins. In diabetes mellitus (DM), the LGs are dysfunctional. The aim of this work was to determine if secretory apparatus changes were associated with any effects on the secretory vesicles (SV) in diabetic rats as well as the expression levels of constituent Rab and members of the SNARE family, and if insulin supplementation reversed those changes. Methods: DM was… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
8
0
1

Year Published

2016
2016
2023
2023

Publication Types

Select...
8
1
1

Relationship

2
8

Authors

Journals

citations
Cited by 18 publications
(9 citation statements)
references
References 26 publications
0
8
0
1
Order By: Relevance
“…Insulin is critical for proliferation of the acinar lacrimal gland (LG) and cornea epithelial cells. Insulin partially reversed the decreased protein expression induced by LG dysfunction; this process is involved in supporting exocytosis and vesicular formation through insulin replacement therapy [ 26 ]. It has been demonstrated that hyperglycemia induces histological alterations in the lacrimal gland, suggesting the role of diabetes-induced oxidative stress in DES [ 27 ].…”
Section: Pathogenesis Of Dm Associated Dry Eye Syndromementioning
confidence: 99%
“…Insulin is critical for proliferation of the acinar lacrimal gland (LG) and cornea epithelial cells. Insulin partially reversed the decreased protein expression induced by LG dysfunction; this process is involved in supporting exocytosis and vesicular formation through insulin replacement therapy [ 26 ]. It has been demonstrated that hyperglycemia induces histological alterations in the lacrimal gland, suggesting the role of diabetes-induced oxidative stress in DES [ 27 ].…”
Section: Pathogenesis Of Dm Associated Dry Eye Syndromementioning
confidence: 99%
“…Insulin receptors were found in lacrimal and ocular surface tissue [29]. At the same time, animal studies have shown that insulin loss causes lacrimal gland shrinkage, corneal innervation, and decreased tear volume [30,31]. In human, insulin resistance was observed with oral estrogen and progesterone replacement therapy in menopause women [32].…”
Section: Discussionmentioning
confidence: 99%
“…Although studies identified the suppression of antioxidant activities as triggers of DE, the action of genetic knockout enzymes may produce other nontracked effects associated with it. Moreover, all other models, including DM, hormone deficiency, and aging, present several competing factors, such as impaired neural transmission and metabolism, hypotrophism, and osmotic imbalance ( Rocha et al, 2003 ; Alves et al, 2005a ; Alves et al, 2005b ; Kojima et al, 2012 ; Uchino et al, 2012 ; Dias et al, 2015 ). Therefore, it is unlikely that OS induced by a deficiency in antioxidant enzymes in the LFU is the only cause of DE in major conditions such as aging, DM, and hormone deficiency.…”
Section: Biological Evidence Of Reactive Oxygen Species In the Lacrim...mentioning
confidence: 99%