2014
DOI: 10.5581/1516-8484.20140012
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Abstract: BackgroundChronic graft-versus-host disease is a serious complication of allogeneic hematopoietic cell transplantation, and the mouth is one of the affected sites.ObjectiveThe aim of this study was to evaluate the oral features of this disease after hematopoietic cell transplantation.MethodsThis was a cross-sectional multicenter study that enrolled patients submitted to transplantation. Oral evaluations used the National Institutes of Health criteria, salivary flow rates, and the range of mouth opening. Pain a… Show more

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Cited by 14 publications
(13 citation statements)
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References 23 publications
(49 reference statements)
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“…Conflicting results for salivary flow rate were found in patients with oral cGVHD. A decreased unstimulated whole salivary (UWS) flow rate was found in patients with aGVHD [17] and those with oral cGVHD (with mucosal lesions, xerostomia, and restricted mouth opening as symptoms) [26,29], whereas no difference in UWS flow rate was reported in 2 studies in which only mucosal lesions were included as oral cGVHD symptoms [27,28] ( Supplementary Table S1).…”
Section: Flow Ratementioning
confidence: 99%
“…Conflicting results for salivary flow rate were found in patients with oral cGVHD. A decreased unstimulated whole salivary (UWS) flow rate was found in patients with aGVHD [17] and those with oral cGVHD (with mucosal lesions, xerostomia, and restricted mouth opening as symptoms) [26,29], whereas no difference in UWS flow rate was reported in 2 studies in which only mucosal lesions were included as oral cGVHD symptoms [27,28] ( Supplementary Table S1).…”
Section: Flow Ratementioning
confidence: 99%
“…This difference may be due to the conservative criteria utilized in the latter study, where the presence of oral lesions was only considered when the NIH scale scores were !3. Overall, the prevalence and incidence of alterations due to cGVHD are reported to vary from 23% to 95%, respectively [14][15][16][17][18][19][20][21].…”
Section: Discussionmentioning
confidence: 99%
“…Manifestations of cGVHD in the salivary glands were very frequent in our patients, which included xerostomia, reduced SFR, and the presence of mucoceles. Although sicca syndrome is a well-documented disorder in GVHD patients, the NIH defines lacrimal dysfunction and xerostomia as GVHD criteria, and no recommendations have been provided for salivary gland involvement by cGVHD [1,27,[35][36][37]. Salivary gland and oral mucosal involvement seem to be distinct manifestations of cGVHD and not extensions of the same pathologic process [36].…”
Section: Discussionmentioning
confidence: 99%