Essential thrombocythemia: a rare disease in childhood

Abstract

Essential thrombocythemia is an acquired myeloproliferative disorder characterized by the proliferation of megakaryocytes in bone marrow, leading to a persistent increase in the number of circulating platelets and thus increasing the risk for thrombotic and hemorrhagic events. The disease features leukocytosis, splenomegaly, vascular occlusive events, hemorrhages and vasomotor disorders. The intricate mechanisms underlying the molecular pathogenesis of this disorder are not completely understood and are still a matter of discussion. Essential thrombocythemia is an extremely rare disorder during childhood. We report on a case of essential thrombocythemia in a child and discuss the diagnostic approach and treatment strategy.

The Frequency and Importance of Hematological Parameters in Reactive and Clonal Thrombocytosis

“…The frequency of reactive thrombocytosis due to infection and tissue injury was 91.8% while clonal thrombocytosis was 8.2% among the 10 patients was founded by Syed NN et al [18]. Beatrice JM [19] stated that among the two types of thrombocytosis such as primary and secondary, the primary as myelo-proliferative disorders rare in children seen in chronic myeloid leukemia, polycythemia, and essential thrombocythemia also called clonal disease derived from a multipotent hematopoietic cell. They also described the signs and symptoms of disease occurring due to the stimulation of the megakaryocytic line, without significant granulocytic and red blood cell stimulation and in these patients, megakaryocytes production takes place due to increased sensitivity to the thrombopoietin stimulation.…”

Cefalea en trombocitosis esencial: reporte de un caso juvenil.

“…La TE con frecuencia se observa entre los 65 a 70 años, con un rango de edad variable, es poco frecuente en menores de 30 años y se presenta predominante en el sexo femenino (1,6,7).…”