2011
DOI: 10.5581/1516-8484.20110030
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Abstract: BackgroundThe study of platelet aggregation is essential to assess in vitro platelet function by different platelet activation pathways.ObjectiveTo assess aggregation and biochemical parameters of random platelet concentrates produced at the Fundação HEMOAM using the quality control tests defined by law.MethodsWhole blood samples from 80 donors and the respective platelet concentrate units were tested. Platelet concentrates were tested (platelet count, aggregation and pH) on days 1, 3 and 5 of storage. Additio… Show more

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Cited by 14 publications
(12 citation statements)
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“…6 The lack of efficacy of platelet transfusion may be attributed to severely reduced ADP reactivity in stored platelet concentrates. [42][43][44] It has been shown that platelet aggregability in stored platelets progressively deteriorates over 5 days with stored platelets, 42,43 although platelet function may recover in vivo over time. 44 In this regard, a shorter-acting P2Y 12 antagonist, cangrelor, may be used as bridging therapy in cases of ACS with an ambiguous diagnosis or a high risk for post-myocardial infarction complications.…”
Section: Discussionmentioning
confidence: 99%
“…6 The lack of efficacy of platelet transfusion may be attributed to severely reduced ADP reactivity in stored platelet concentrates. [42][43][44] It has been shown that platelet aggregability in stored platelets progressively deteriorates over 5 days with stored platelets, 42,43 although platelet function may recover in vivo over time. 44 In this regard, a shorter-acting P2Y 12 antagonist, cangrelor, may be used as bridging therapy in cases of ACS with an ambiguous diagnosis or a high risk for post-myocardial infarction complications.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, it binds to von Willebrand factor (vWF), creating an adherence bridge between collagen and the platelet glycoprotein Ib receptor. Granule content secretion is triggered by platelet surface receptor agonists 22 . In our study, the results of platelet aggregation showed that after 5 days of storage a reproducible aggregation response could be determined, but there was statisticaly significant decrease in platelet aggregation on the third and fifth day of storage compared to the first day.…”
Section: Discussionmentioning
confidence: 99%
“…Nutritional polyphenols may also influence platelet aggregation . Secondly, distinct reduced ADP‐activated platelet aggregation in stored platelet concentrates is already observed after 24 h , increasing variance (CV) of ADP‐activated IQC measurements near zero values (% aggregation and AUC). Higher doses of ADP may overcome this major limitation and increased amount of plasma in the storage solution reduces deterioration of platelet responsiveness to ADP, as reported by Keuren et al .…”
Section: Discussionmentioning
confidence: 99%