N-(Dibenzylcarbamothioyl)-3-methylbutanamide: Crystal structure, Hirshfeld surfaces and antimicrobial activity

Abstract

The compound N-(dibenzylcarbamothioyl)-3-methylbutanamide as a thiourea derivative was synthesized and structurally characterized by NMR and FT-IR spectroscopic techniques. The molecular structure of compound was also characterized by single crystal X-ray diffraction method. Crystal data for title compound C20H24N2OS: monoclinic, space group C2/c (no. 15), a = 19.6882(9) Å, b = 9.4045(4) Å, c = 19.5012(8) Å, β = 98.433(2)°, V = 3571.8(3) Å3, Z = 8, μ(CuKα) = 1.665 mm-1, 25057 reflections measured (9.168° ≤ 2Θ ≤ 144.196°), 3500 unique (Rint = 0.0322, Rsigma = 0.0200) which were used in all calculations. The final R1 was 0.0363 (I>2σ(I)) and wR2 was 0.0910 (all data). Intermolecular contacts obtained from X-ray single crystal diffraction study were also explored using both Hirshfeld surfaces and fingerprint plots. Hirshfeld surface analysis showed the occurrence of S···H, O···H and H···H contacts that display an important role to crystal packing stabilization of the thiourea derivative compound. In addition, the compound was evaluated for both their in-vitro antibacterial and antifungal activity.

Ru(II) and Ru(III) complexes containing N‐acylthiourea ligands: Supramolecular structures and synthons, reduction, and reaction pathway of aromatic nitro compounds

“…The bond distances of C1-N1 = 1.325(5), C8-N1 = 1.352(5) Å in the coordinated benzoylthiourea ligand are significantly shorter than the average length of a single C-N bond (1.48 Å). [55][56][57][58] Furthermore, the carbonyl and thiocarbonyl bond distances (O1-C1 = 1.267(5) and S1-C8 = 1.740 (4) Å) of the coordinated ligand are longer than the bond lengths of the corresponding double bond distances of the benzoylthioureas, [58][59][60][61][62][63] and these data show electron delocalization within the chelate ring.…”

Synthesis, characterization and crystal structure of platinum(II) complexes with thiourea derivative ligands

“…For example N-(alkyl/aryl)-N'-acylthiourea and N-di(alkyl/aryl)-N'-acylthiourea derivatives which have oxygen, nitrogen and sulphur donor atoms, exhibit prevalent coordination modes. Organic ligands that have thiourea moiety are able to bind metal ions in several ways, like: (i) acting as monodentate ligands through sulphur atom in mononuclear complexes [1-4] (ii) binding to metal ions forming S-bridges in dinuclear complexes [4][5][6][7][8] or (iii) chelating sulphur and nitrogen atoms [4][5][6][8][9][10][11][12][13][14][15][16] Thiourea derivatives as a ligand have a large dipole moment and these ligands can also form extensive network of hydrogen bonds due to their unique structures. For example in 3-monosubstituted arylthioureas [17][18][19], the carbonyl group and the proton on the nitrogen attach in a strong hydrogen bond interaction which unite into a planar six-membered ring structure forming an "S" shaped conformation of the C=O and C=S groups [20,21].…”