Synthesis and antiproliferative activity of 3-(substituted)-4,5,6,7-tetrahydro-6-(substituted)-1H-pyrazolo[3,4-c]pyridine derivatives

Pawar, Chandrakant D.; Pansare, Dattatraya N.; Shinde, Devanand B.

doi:10.5155/eurjchem.8.4.400-409.1645

Cited by 13 publications

(8 citation statements)

References 14 publications

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“…In view of the above considerations, in continuation of our previous work on triazoles, pyrimidine, thiazoles and thiazolidinones of pharmaceutical interest [24][25][26][27][28][29][30] we report here on the synthesis and anticancer activity of new 3-(indoline-1-carbonyl)-N-(substituted) benzene sulfonamide analogs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Anticancer Evaluation of Benzenesulfonamide Derivatives

Pansare¹,

Shelke²

2020

Heterocycles - Synthesis and Biological Activities

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A highly efficient protocol was developed for the synthesis of 3-(indoline-1carbonyl)-N-(substituted) benzene sulfonamide analogs with excellent yields. The new 3-(indoline-1-carbonyl)-N-(substituted) benzene sulfonamide derivatives (4a-g and 5a-g) were evaluated in vitro anticancer activity against a series of different cell lines like A549 (lung cancer cell), HeLa (cervical), MCF-7 (breast cancer cell) and Du-145 (prostate cancer cell) respectively. The results of the anticancer activity data revealed that most of the tested compounds showed IC 50 values from 1.98 to 9.12 μM in different cell lines. Compounds 4b, 4d, 5d, and 5g were the most potent, with IC 50 values ranging from 1.98 to 2.72 μM in different cell lines.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Anticancer Evaluation of Benzenesulfonamide Derivatives

Pansare¹,

Shelke²

2020

Heterocycles - Synthesis and Biological Activities

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“…15 Some benzthiazole forms key building block of some of the biologically active derivatives. [16][17] By considering the diversified biological activity of benzo [d]thiazol and continuation of our research work, [18][19][20] we have synthesized a series of substitutedbenzo [d]thiazole derivatives and all the synthesized compounds were tested for their biological activity in cell line and enzymatic study.…”

Section: Introductionmentioning

confidence: 99%

SYNTHESIS OF NOVEL SUBSTITUTED-BENZO[d]THIAZOLE-2,4-DICARBOXAMIDES HAVING KINASE INHIBITION AND ANTI-PROLIFERATIVE ACTIVITY

Gaikwad¹,

Pawar²,

Pansare³

et al. 2019

ECB

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A series of novel derivatives containing N 4-(4-fluorophenyl)-N 2-substitured-benzo[d]thiazole-2,4-dicarboxamides were synthesized via an efficient, mild and convenient multistep reaction protocol with excellent yields. The structure of the synthesize compounds were confirmed by IR, 1 H NMR, 13 C NMR, 19 F NMR, mass spectra, elemental analysis and purity was checked by HPLC. All synthesized compounds were screened for anticancer activity against A-549 and Du-145 cancer cell lines by MTT assay. The preliminary bioassay suggests that most of the compounds show anti-proliferation with different degrees. The synthesized compound shows IC50 values in the range of 1.52-17.18 µM in both cell lines. The compounds having electron donating groups had higher anticancer activity compared compounds with electron withdrawing substitutions.

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“…32,33 Ultrasonic irradiation has been acknowledged as an innocuous, green technique and its application today has been a boon in serving a new pathway for several chemical processes like reagent activation in the synthesis of organic and inorganic compounds. 34 In view of the above considerations and in continuation of our previous work on thiazoles, thiazolidinones and sulphonamide derivatives of pharmaceutical interest, [35][36][37][38][39][40][41][42][43][44][45][46][47] we wish to report a simple, mild, competent and environmentally benign method for the synthesis and characterization of novel rhodanine derivatives 3, 4 and 6a-l by ultrasound irradiation and conventional technique via potassium carbonate catalyzed in water media.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of 4-methoxybenzylidene thiazole derivatives using potassium carbonate as base under ultrasound irradiation

Pansare¹,

Shelke²,

Pawar³

et al. 2019

10.5267/j.ccl

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An environmentally benign aqueous protocol for the synthesis of novel 2-((5-(4methoxybenzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)amino)substituted acid by using potassium carbonate as a base has been achieved. These ultrasound irradiation and conventional technique reaction proceed efficiently in water in the absence of organic solvent. In comparison with conventional methods, our protocol is convenient and offers several advantages, such as shorter reaction time, higher yields, milder conditions and environmental friendliness.

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Synthesis and antiproliferative activity of 3-(substituted)-4,5,6,7-tetrahydro-6-(substituted)-1H-pyrazolo[3,4-c]pyridine derivatives

Cited by 13 publications

References 14 publications

Synthesis and Anticancer Evaluation of Benzenesulfonamide Derivatives

Synthesis and Anticancer Evaluation of Benzenesulfonamide Derivatives

SYNTHESIS OF NOVEL SUBSTITUTED-BENZO[d]THIAZOLE-2,4-DICARBOXAMIDES HAVING KINASE INHIBITION AND ANTI-PROLIFERATIVE ACTIVITY

Green synthesis of 4-methoxybenzylidene thiazole derivatives using potassium carbonate as base under ultrasound irradiation

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