Synthesis of quinazolinones derivatives an antiproliferative agent against human lung carcinoma cells

Abstract

2,3-Dihydroquinazolin-4(1H)-one derivatives (3a-p) were synthesized in excellent yields. These compounds were screened for antiproliferative activity against A549 cells and were found as potent cytotoxicity. Compounds A4, A8, A10 found to be more promising antiproliferative against the lung carcinoma A549 cells. IC50 values for compounds A4, A8 and A10 were found to be 8.6, 8.9 and 8.1 μg/L against A549 cells, respectively. KEYWORDS Ionic liquidGreen chemistry 2-Aminobenzamide Antiproliferative activity Lung carcinoma A549 cells 2,3-Dihydroquinazolin-4(1H)-one Cite this: Eur.

An Efficient and Green Synthesis of Tetrahydrobenzo[b]Pyran Derivatives Using [(EMIM)Ac] at Room Temperature

“…The use of ionic liquid as a catalyst is another green technique used in organic synthesis. Ionic liquid has received considerable attention as an environmentally friendly solvent as well as catalyst [6–8] . Ionic liquids (ILs) own various properties including thermal stability, flammability, low viscosity, low volatility, negligible vapors pressure, and a wide range of solubility.…”

“…Ionic liquid has received considerable attention as an environmentally friendly solvent as well as catalyst. [6][7][8] Ionic liquids (ILs) own various properties including thermal stability, flammability, low viscosity, low volatility, negligible vapors pressure, and a wide range of solubility. Ionic liquids (ILs) own the potential to bring about fundamental and essential changes in synthetic ways by replacing conventional reagents.…”

Synthesis of 2,3-dihydroquinazolinones using nano-ovalbumin as a non-toxic biocatalyst

“…2,3-Dihydroquinazolin-4(1H)-ones are a significant class of heterocyclic compounds that form vary useful moiety of pharmaceutical, agricultural chemical and veterinary products [1,2]. Quinazolinone and its derivatives have many biological and medicinal activities such as anticonvulsant [3], antitumor [4], anticancer [5], hypnotic/sedatives [6], antimalarial [7], antibacterial and antioxidant [8], antimicrobial [9], antifungal and cytotoxic [10], antiproliferative [11], and inhibitory activities on α-glucosidase [12]. Several examples of marketed drugs with the 2,3-dihydroquinozolinones (DHQ) framework are shown in Fig.…”

Synthesis of 2,3‐dihydroquinazolin‐4(1H)‐ones in the presence of Fe3O4@nano‐cellulose–OPO3H as a bio‐based magnetic nanocatalyst

“…Quinazolinones and their derivatives are used to synthesize similar drugs such as hypnotic/sedatives and antimalarial, antibacterial and antioxidant, antitumor, antifungal and cytotoxic, antiproliferative, and inhibitory activities on α‐glucosidase . In Figure , the structure of metolazon (hypertensive), febrifugine (antimalaria), and methaqualone (sedative) were shown.…”