Synthesis and antimicrobial evaluation of substituted fluoroquinolones under conventional and microwave irradiation conditions

Abstract

A series of new fluoroquinolones analogs (3a-i) were prepared under conventional and microwave irradiation technique. Ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4dihydroquinoline-3-carboxylate (1) on reaction with boric acid and acetic anhydride in the presence of catalytic amount of zinc chloride under reflux, resulted in an unstable borate complex. Which was instantaneously treated with morpholine, piperidine, thiomorpholine, 2,6-dimethylmorpholine, 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride, 5,6,7,7atetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride, 2,3-dichlorophenylpiperazine hydrochloride, 3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride and 5,6,7,8-tetrahydro-[1,2,4] triazolo[4,3-a]pyrazine, in the presence of triethylamine to yield compounds 3a-i. The same compounds on the other hand synthesized using a microwave irradiation technique in the presence of triethylamine and adsorbed neutral alumina. The structures of the synthesized compounds were established on the basis of spectral and analytical data. The antimicrobial activity of newly synthesized compounds were evaluated against different microorganisms and found the compounds exhibited significant activity.

Copper(I)‐Catalyzed Azide‐Alkyne Cycloaddition Microwave‐Assisted: Preparation of 7‐(4‐Substituted‐1H‐1,2,3‐Triazol‐1‐yl)‐Fluoroquinolones

“…The most successful compounds developed are based on modifications at C‐7, and it has been found that the spectrum, level of antibacterial activity, inhibition of DNA gyrase or topoisomerase IV, and cell permeability are highly affected by the nature of the C‐7 substituent group. Substituents that have been studied included: medium‐sized N ‐heterocyclic ring (5‐ and 6‐membered), N ‐substituted piperazine, linear substituents with one or two heteroatoms (‐NHNH 2 , ‐NHR, ‐NHCH 2 CH 2 NH 2 ), methyl‐, chloro‐, and 1,2,3‐triazole‐derivatives The 1,2,3 moiety does not occur in nature, although the synthetic molecules containing 1,2,3‐triazole unit show diverse biological activities including anti‐obesity, antiallergic, antibacterial, antiparasitic, herbicidal, fungicidal, and anti‐HIV…”