2017
DOI: 10.5155/eurjchem.8.1.8-12.1514
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Abstract: Simple, selective and precise spectrophotometric methods were applied for simultaneous quantification of sofosbuvir (SFV) and ledipasvir (LDI) both in their raw and dosage forms. In the first method, the two cited drugs were determined simultaneously using first derivative (D 1 ) method. It was accomplished by measuring peak heights at 275 nm and 344 nm, for SFV and LDI, respectively, in concentration ranges of 5 -80 μg/mL and 3 -50 μg/mL, for SFV and LDI, respectively. In the second one, a first derivative of… Show more

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Cited by 4 publications
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“…1 Table I depicts the comparison of the limit of detection (LOD) of the various reported methods for Ledipasvir determination along with the proposed square-wave-adsorptive anodic stripping voltammetric (SW-AdASV) method. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] LC-MS/MS and spectrofluorimetric methods [2][3][4]12 are very sensitive and selective but expensive. TLC, 5 HPLC [6][7][8][9] and spectrophotometry [9][10][11] techniques have also serious drawback, such as low sensitivity, Table I.…”
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confidence: 99%
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“…1 Table I depicts the comparison of the limit of detection (LOD) of the various reported methods for Ledipasvir determination along with the proposed square-wave-adsorptive anodic stripping voltammetric (SW-AdASV) method. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] LC-MS/MS and spectrofluorimetric methods [2][3][4]12 are very sensitive and selective but expensive. TLC, 5 HPLC [6][7][8][9] and spectrophotometry [9][10][11] techniques have also serious drawback, such as low sensitivity, Table I.…”
mentioning
confidence: 99%
“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] LC-MS/MS and spectrofluorimetric methods [2][3][4]12 are very sensitive and selective but expensive. TLC, 5 HPLC [6][7][8][9] and spectrophotometry [9][10][11] techniques have also serious drawback, such as low sensitivity, Table I. According to pharmacokinetic study, 3,4 Ledipasvir attains the maximum human plasma concentrations (C max ) of (0.172-2.25 μM) while the minimum concentrations (C min ) were (5.06-5.62 nM) upon administration of a single oral dose of Harvoni® tablets.…”
mentioning
confidence: 99%