Pharmacological evaluation of ONNO donor quadridentate Schiff bases

Abstract

Four ONNO donor Schiff bases 2-((E)-(2-((E)-2-hydroxybenzylideneamino)ethylimino) methyl)phenol (H2L1), 2-((E)-(2-((E)-2-hydroxybenzylideneamino)propylimino)methyl) phenol (H2L2), 2-((E)-1-(2-((E)-1-(2-hydroxyphenyl) ethylideneamino)ethylimino)ethyl) phenol (H2L3) and 2-((E)-1-(2-((E)-1-(2-hydroxyphenyl)ethylideneamino)propylimino) ethyl)phenol (H2L4) were synthesized by the reactions of ethylene/propylene diamines with 2-hydroxy benzaldehyde/2-hydroxy acetophenone. The new compounds were characterized by FT-IR and NMR (1 H and 13 C) spectroscopic techniques accompanied by elemental, GC/MS and single crystal X-ray diffraction analyses. These compounds were screened for various biological studies i.e. brine shrimp cytotoxic, antitumor and antibacterial activities The compound H2L3 showed highest cytotoxic and antitumor activities with lowest LD50 (14.27) and IC50 values (18.90). All the compounds were highly active in protecting DNA against hydroxyl free radicals. Antibacterial studies had shown that these were inactive against Gram positive bacteria (Staphylococcus aureus and Micrococcus luteus) while active against Gram negative bacteria (Enterobacter aerogenes, Bordetella bronchiseptica and Salmonella typhi) showing variable antibacterial activity.

Synthesis, Crystal Structure, Hirshfeld Surface Analysis, and Computational Study of a Novel Organic Salt Obtained from Benzylamine and an Acidic Component

“…Use of aldehydes is usually preferred over ketones due to the faster rate of condensation reaction . Schiff bases have azomethine (−HCN) linkage, where the nitrogen atom is sp 2 -hybridized and has a lone pair, which is attributed to the potential biological applications in the fields of pharmacology, anticancer, antibacterial, antifungal, antiviral, antioxidant, and anti-parasitic activities. − …”

Investigation on Spectroscopic, Thermal and Antimicrobial Activity of Newly Synthesized Binuclear Cr(III) Metal Ion Complex

“…The data from the TGA clearly indicated that the decomposition of the complex proceeds in four or five steps. In the first step of decomposition two chlorine atoms were lost between 30°C to ~331°C (calculated 8.10%, experimental 7.75% of weight) [28,29]. Four molecules of coordinated water molecules are gradually decomposed between temperatures 332°C to 384.4°C (calculated 8.508%, experimental 8.85% of weight) in second step of decomposition [30].…”

Structural characterization, biological evaluation and DNA interaction of some potential drugs based on bifunctional aldehyde functionality

“…Brine shrimp lethality assay was used to assess the cytotoxicity of the compounds [26,27]. Artificial sea water (pH = 7.4) was prepared by dissolving commercial sea salt (34 g/mL) in distilled water.…”

“…Potato disc antitumor assay was performed to assess the antitumor activity of the test compounds [27,28]. The assay was performed in aseptic conditions.…”