Synthesis and characterization of tri- and tetra-metallic complexes of N'1,N'4-bis((E)-3,4-dihydroxybenzylidene)-succinohydrazide

El‐Asmy, Ahmed A.; Jeragh, Bakir; Ali, Mayada S.

doi:10.5155/eurjchem.7.1.81-90.1356

Cited by 3 publications

(5 citation statements)

References 21 publications

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“…The ν(C=N) band is shifted to lower wavenumber indicating its coordination. Also, the IR spectra of the complexes showed a new band at 461-542 and 420-450 cm -1 due to ν(M-O) and ν(M-N) as well as a new one at 1338 cm -1 due to δ(OH) of the coordinated water [18].…”

Section: Ir and Nmr Spectramentioning

confidence: 96%

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Chelation activity of N'1,N'6-bis((E)-3,4-dihydroxybenzylidene)adipohydrazide towards some transition metal ions

2016

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New chelating agent, N'1,N'6-bis((E)-3,4-dihydroxybenzylidene)adipohydrazide (DBAH) was synthesized and its crystal structure was analyzed by X-ray single crystal diffractometer. Homometallic complexes of Zr(IV), Co(II), Ni(II), Cu(II), Cd(II) and heterometallic complex of Co(II)/Zn(II) or Co(II)/Zn(II)/Cd(II) have been synthesized and characterized by spectroscopic and physicochemical methods. The data confirms the formation of bi-and tetra-metallic complexes. The ligand behaves as a neutral tetradentate in the Co(II) and Ni(II) complexes; tetranegative tetradentate in Zr(IV) and Cd(II) complexes and binegative octadentate in [Co2Zn2(DBAH)Cl6] and [Co2ZnCd(DBAH-4H)(H2O)4Cl4].H2O. A tetrahedral structure was proposed for the Ni(II), Zr(IV) and Co(II)/Zn(II) complexes; square-planar for the Cu(II) complex and octahedral geometry for the Co(II) complex. The ESR spectrum confirms the proposed structure of the Cu(II) complex. The thermal analyses confirm the stability of these complexes in the range 275-418 °C. The molecular modeling of [Co2Zn2(DBAH)Cl8] was drawn and its parameters were calculated.

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Section: Ir and Nmr Spectramentioning

confidence: 96%

“…In continuation of our ongoing studies on dihydrazone ligands [14][15][16][17][18][19][20][21], we have synthesized and characterized new metal complexes of Zr(IV), Co(II), Ni(II), Cu(II), and Cd(II) ions with N'1,N'6-bis((E)-3,4-dihydroxybenzylidene)adipohydrazide.…”

Section: Introductionmentioning

confidence: 99%

Chelation activity of N'1,N'6-bis((E)-3,4-dihydroxybenzylidene)adipohydrazide towards some transition metal ions

2016

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“…The data proved mono hydrazones' ability to kill cancer cells and their potent effect on genome instability (Amato et al, 2020). Previously, several series of hydrazone anticancer compounds were synthesized, well-characterized, and proved to be anticancer agents (El-Asmy et al, 2016. Based on that, in the present research hydrazone derivative (N'1E,N'3E)-N'1,N'3-bis(2-hydroxybenzylidene)-isophthalohydrazide [H4L] ligand and its Mn ligand complex were designed, synthesized, and spectroscopically characterized.…”

Section: Introductionmentioning

confidence: 93%

“…The color of the reaction mixture directly changed and formed a colored precipitate which was filtered, washed, and dried overnight. The purity of the compounds was formulated and established by microanalysis (El-Asmy et al, 2016.…”

Section: Synthesis Of Mn Ligand Complexmentioning

confidence: 99%

Hydrazone bimetallic complex: synthesis, characterization, in silico and biological evaluation targeting breast and lung cancer cells’ G-quadruplex DNA

Ali

Kuraijam

Karnik

et al. 2022

KJS publishes peer-review articles in Mathematics, Computer Sci

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Manganese complex of (N'1E,N'3E)-N'1,N'3-bis(2-hydroxybenzylidene)isophthalo-hydrazide [H4L] was designed, spectroscopically analyzed, and confirmed via GC-MS, FTIR, CHNS, UV-VIS, magnetic susceptibility measurements, and molar electric conductivity. The data confirmed the formation of ligand H4L and [Mn2(H2L)Cl]Cl.2H2O complex. Ligand H4L acts as a bi-negative hexadentate and tetra-negative hexadentate coordinating through two amide carbonyl, two azomethine, and two deprotonated OH groups. The magnetic and spectral data proposed a square-planar and a tetrahedral structure. The TGA data confirmed the final metal oxide form for the Mn ligand complex. Additionally, an in-vitro assessment of the ligand H4L confirmed its ability to control cancer cell proliferation in both breast (MCF7) and lung (A549) cancer cell lines while the Mn ligand complex possessed an anticancer effect in both cancer cells at the nano-molar level. Further, the in silico data showed four hydrogen bond interactions of the ligand with G-quadruplex DNA. This strengthens our hypothesis that the hydrazone complex acts as an anticancer agent by targeting the G-quadruplex DNA.

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“…One-dimensional chains along the a-axis direction formed by N-H� � �O hydrogen bonding. 2009), NAJWUT (Singh et al, 2016), NEQQOQ (Zhu et al, 2006), RIRTET (Singh et al, 2014), SUYWUG (Galva ˜o et al, 2016), UMIZUN (El-Asmy et al, 2015), ZOLQUP and ZOLRAW (Fries et al, 2019). For compound ZOLQOJ (Fries et al, 2019), the fragment is part of a ring structure.…”

Section: Figurementioning

confidence: 99%

Synthesis and crystal structure of N ¹,N ²-dimethylethanedihydrazide

Bibik,

Khomenko,

Doroshchuk

et al. 2024

Acta Cryst E

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The title compound, N 1,N 2-dimethylethanedihydrazide, C4H10N4O2, was obtained by the methylation of oxalyl dihydrazide protected with phthalimide. The molecule is essentially non-planar with a dihedral angle between the two planar hydrazide fragments of 86.5 (2)°. This geometry contributes to the formation of a multi-contact three-dimensional supramolecular network via C—H...O, N—H...O and N—H...N hydrogen bonds.

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Synthesis and characterization of tri- and tetra-metallic complexes of N'1,N'4-bis((E)-3,4-dihydroxybenzylidene)-succinohydrazide

Cited by 3 publications

References 21 publications

Chelation activity of N'1,N'6-bis((E)-3,4-dihydroxybenzylidene)adipohydrazide towards some transition metal ions

Chelation activity of N'1,N'6-bis((E)-3,4-dihydroxybenzylidene)adipohydrazide towards some transition metal ions

Hydrazone bimetallic complex: synthesis, characterization, in silico and biological evaluation targeting breast and lung cancer cells’ G-quadruplex DNA

Synthesis and crystal structure of N ¹,N ²-dimethylethanedihydrazide

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Synthesis and characterization of tri- and tetra-metallic complexes of N'1,N'4-bis((E)-3,4-dihydroxybenzylidene)-succinohydrazide

Cited by 3 publications

References 21 publications

Chelation activity of N'1,N'6-bis((E)-3,4-dihydroxybenzylidene)adipohydrazide towards some transition metal ions

Chelation activity of N'1,N'6-bis((E)-3,4-dihydroxybenzylidene)adipohydrazide towards some transition metal ions

Hydrazone bimetallic complex: synthesis, characterization, in silico and biological evaluation targeting breast and lung cancer cells’ G-quadruplex DNA

Synthesis and crystal structure of N 1,N 2-dimethylethanedihydrazide

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Synthesis and crystal structure of N ¹,N ²-dimethylethanedihydrazide