Simultaneous determination of carbinoxamine maleate and pseudoephedrine HCl in their pure form and in their pharmaceutical formulation by HPTLC-densitometric method

Abdelrahman, Maha M.; Abdelaleem, Eglal A.; Ali, Nouruddin W.; Emam, Raghda Abdelmoneim

doi:10.5155/eurjchem.7.1.37-41.1355

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…PSE is official in the BP [3]. Several methods were found in the literature for its quantitation such as titrimetry [3], spectrophotometry [17, 18], HPTLC [19, 20],GC [21], Micellar electrokinetic chromatography (MEKC) [22], HPLC–UV [23, 24] and capillary electrophoresis (CE) [25]. BRM; (3RS)-3-(4-Bromophenyl)- N , N -dimethyl-3-(pyridin-2-yl)propan-1-amine(Z)-butenedioate, is an antihistamine used for relieving allergy symptoms such as sneezing, itching and watery eyes [26].…”

Section: Introductionmentioning

confidence: 99%

Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets

et al. 2019

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Comtrex ® tablets composed of paracetamol, pseudoephedrine and brompheniramine are widely used for relieving symptoms related to common cold. This study has overcome the challenging dosage form ratio (250:15:1) and proposed chromatographic methods for analyzing the ternary combination were utilized displaying different apparatus, solvents and sensitivity ranges. Three chromatographic methods namely thin layer chromatography (TLC), high performance liquid chromatography with ultra-violet detection (HPLC–UV) and ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) were developed and validated for the simultaneous determination of the three drugs. Concerning the TLC method, aluminum TLC plates pre-coated with silica gel 60F 254 were used and methanol:water:ammonia (9:1:0.1, v/v/v) was applied as a mobile phase; scanning of the plates was carried out at 254 nm. For the HPLC–UV method C 18 column was used with an isocratic elution mobile phase composed of water:acetonitrile (75:25, v/v; pH 3.2) and the detection was at 210 nm. For the UPLC-MS/MS method; separation was performed on a UPLC-BEH C 18 column with methanol: 0.1% ammonium formate (60:40, v/v) as the mobile phase utilizing diphenhydramine as an internal standard and mass spectrometry was used for detection. The methods were simple, sensitive, accurate and precise. Statistical analysis revealed no significant difference from the reported methods in regard to accuracy and precision. Electronic supplementary material The online version of this article (10.1186/s13065-019-0595-6) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets

et al. 2019

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“…A review in literature has revealed that many chromatographic methods have been used for carbinoxamine determination in phar-maceutical dosage form [7][8][9][10][11][12][13] but few methods have been reported for determination of Carbinoxamine in plasma [14][15][16]. Those methods have included HPLC coupled with UV [16], HPLC with coulometric detection [17], or with LC-MS/MS [14,15].…”

Section: Introductionmentioning

confidence: 99%

Simple HPLC Method for Quantitative Determination of Carbinoxamine in Human Plasma: Application in Pharmacokinetic Studies and Therapeutic Drug Monitoring

El-Masry

El-Morsi

2019

Drug Res (Stuttg)

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A sensitive, specific and cost-effective HPLC method was developed for quantitative determination of carbinoxamine in human plasma using liquid chromatography with ultraviolet detection. A simple liquid–liquid extraction by ethyl acetate was used to extract carbinoxamine from human plasma. Satisfactory separation was achieved by a mobile phase consisting of 20 mM ammonium dihydrogen orthophosphate containing 0.01% triethyl amine (pH adjusted to 3 by using phosphoric acid) and acetonitrile in ratio of (75:25, v/v) at a flow rate of 0.9 mL/min on Hypersil® BDS C18 column (250×4.6 mm, 5 μm) column. The UV detector was set at 260 nm. The developed method was validated in human plasma with a lower limit of quantitation of 5 ng/mL for carbinoxamine. Linearity was demonstrated over the concentration range 5–200 ng/mL. The observed within- and between-day assay precision ranged from 1.902 to 14.90%; accuracy varied between 98.87 and 108.0%. This method can be used suitably for pharmacokinetic studies and in therapeutic drug monitoring in patients treated with carbinoxamine.

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“…[28] PSE is official in the BP. [4] Several methods were found in the literature for its determination including titrimetry, [4] spectrophotometry, [29][30][31][32] TLC, [15,[33][34][35][36] GC, [37,38] Micellar electrokinetic chromatography (MECK), [39][40][41] HPLC-UV [21-24, 30, 42-45] and capillary electrophoresis (CE). [46][47][48][49] BRM;…”

Section: Introductionmentioning

confidence: 99%

Analysis of Paracetamol, Pseudoephedrine and Brompheniramine in Comtrex® Tablets Using Chemometric Methods

Youssef¹

2017

WJPPS

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Paracetamol (PAR), pseudoephedrine hydrochloride (PSE) and brompheniramine maleate (BRM) are co-formulated drugs that are widely used in the Egyptian market for the relief of symptoms associated with common cold. Their severely overlapped spectra were resolved by two simple, accurate and precise chemometric techniques, principal component regression method (PCR) and partial Least Squares methods (PLS). The proposed methods were rapid, cost effective and were successfully applied for the analysis of laboratory prepared mixtures and the combined dosage form. Good recoveries were obtained for PCR method, 100.42, 100.05 and 98.96 % and for PLS method 100.04, 99.95 and 100.36 % for PAR, PSE and BRM, respectively. The methods were validated according to the ICH guidelines. Comparison of the applied methods with the reported method was done and no significant difference was found regarding accuracy and precision.

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Simultaneous determination of carbinoxamine maleate and pseudoephedrine HCl in their pure form and in their pharmaceutical formulation by HPTLC-densitometric method

Cited by 5 publications

References 18 publications

Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets

Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets

Simple HPLC Method for Quantitative Determination of Carbinoxamine in Human Plasma: Application in Pharmacokinetic Studies and Therapeutic Drug Monitoring

Analysis of Paracetamol, Pseudoephedrine and Brompheniramine in Comtrex® Tablets Using Chemometric Methods

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