One pot synthesis of 1-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d] imidazoles in ionic liquids: Evaluation of antioxidant and antimicrobial activities

Seeka, Suresh; Narsimha, Sirassu; Battula, Kumaraswamy; Shaikh, A.H.; Tangeda, Savitha Jyostna; Nagavelli, Vasudeva Reddy

doi:10.5155/eurjchem.6.4.482-487.1325

Cited by 10 publications

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References 32 publications

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“…In recent years, chemical and biological usefulness of heterocyclic compounds attracted attention of chemist in form of pharmaceuticals, agrochemicals, polymers, dyes, etc . Triazole, a five‐membered heterocycle is key important, as its derivatives exhibited various biological activities such as antibacterial, antimalarial, antitubercular, anticancer, antiparasitic, antileishmanial, antioxidant, anti‐inflammatory, antidepressant, antiviral, etc. The 1,2,3‐triazole derivatives play an intriguing role in the development of new drugs, as effectively exerts various non‐covalent interactions which improves the solubility and the ability of binding to bimolecular targets …”

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confidence: 99%

Synthesis, antibacterial, and antioxidant activities of naphthyl‐linked disubstituted 1,2,3‐triazoles

Kaushik

Luxmi

2020

Journal of Heterocyclic Chem

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Here, click synthesis of 15 naphthyl‐linked disubstituted 1,2,3‐triazoles has been carried out by the reaction between 1‐(prop‐2‐yn‐1‐yloxy)naphthalene and aromatic azides. The structure elucidation of the synthesized compounds was carried out by FTIR, 1H NMR, 13C NMR, and HRMS techniques. Further, the compound 7f was confirmed by X‐ray crystallography (CCDC 1876891). The synthesized compounds were explored for antibacterial activity against Bacillus cereus, Escherichia coli, and Staphylococcus aureus. Biological evaluation of synthesized 1,2,3‐triazoles revealed moderate to good antibacterial activity against the tested strains. The antioxidative behavior of synthesized compounds manifested the remarkable free radical scavenging activity using DPPH assay.

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Section: Introductionmentioning

confidence: 99%

Synthesis, antibacterial, and antioxidant activities of naphthyl‐linked disubstituted 1,2,3‐triazoles

Kaushik

Luxmi

2020

Journal of Heterocyclic Chem

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Synthesis and Biological Evaluation of Novel Thiomorpholine 1,1-Dioxide Derived 1,2,3-Triazole Hybrids as Potential Anticancer Agents

et al. 2017

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In this report, we describe the synthesis and biological evaluation of a new series of (4‐((1‐(aryl)‐1H‐1,2,3‐triazol‐4‐yl)methoxy)phenyl)(1,1‐dioxidothiomorpholino)methanone derivatives (6 a‐6 n). All the new derivatives were well analyzed by 1H NMR, 13C NMR, FTIR, mass spectral and elemental data. The synthesized compounds were screened for in vitro anticancer activity against three cancer cell lines (MCF‐7, HeLa, and HEK293) and compared with standard drug cisplatin. Three (6 b, 6 g and 6 i) out of fourteen derivatives exhibited potent anticancer activity against MCF‐7, HeLa, and HEK293. Two (6 b and 6 g) potent hybrids were screened for in vivo studies against EAC bearing mice and found to possess potential anticancer activity.

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Synthesis and Biological Evaluation of (N-(3-methoxyphenyl)-4-((aryl-1H -1,2,3-triazol-4-yl)methyl)thiomorpholine-2-carboxamide 1,1-Dioxide Hybrids as Antiproliferative Agents

et al. 2017

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A series of new thirteen N‐(3‐Methoxyphenyl)thiomorpholine‐2‐carboxamide 1, 1‐dioxide derived 1, 4‐disubtituted 1, 2, 3‐triazole hybrids (7 a‐7 m) were synthesized by Cu (I) catalyzed cycloaddition reaction and well characterized by 1H NMR, 13 C NMR, FTIR, mass spectral and elemental analysis data. All the hybrid compounds were subjected to in vitro anticancer activity against three human cancer cell lines MCF‐7, Hela and A‐549 and 2‐hydroxy phenyl, 2‐methoxy phenyl and 3‐methoxy phenyl substituted (7 f, 7 g and 7 h) derivatives were found to possess potential antiproliferative activity.

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One pot synthesis of 1-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d] imidazoles in ionic liquids: Evaluation of antioxidant and antimicrobial activities

Cited by 10 publications

References 32 publications

Synthesis, antibacterial, and antioxidant activities of naphthyl‐linked disubstituted 1,2,3‐triazoles

Synthesis, antibacterial, and antioxidant activities of naphthyl‐linked disubstituted 1,2,3‐triazoles

Synthesis and Biological Evaluation of Novel Thiomorpholine 1,1-Dioxide Derived 1,2,3-Triazole Hybrids as Potential Anticancer Agents

Synthesis and Biological Evaluation of (N-(3-methoxyphenyl)-4-((aryl-1H -1,2,3-triazol-4-yl)methyl)thiomorpholine-2-carboxamide 1,1-Dioxide Hybrids as Antiproliferative Agents

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