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Cited by 8 publications
(6 citation statements)
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“…Further optimizations related to the amounts of DBU and phenyl isothiocyanate (entries 8-10) showed that the use of 3 equivalents of phenyl isothiocyanate allowed a significant improvement of the NMR yield (54%, entry 9). Afterwards, the dilution effect was examined (entries [11][12][13][14]. Optimal conditions using 0.1 M pyrazole 4c, DBU (1 equiv), and phenyl isothiocyanate (3 equiv) led to 7a in an improved 70% NMR yield and 45% isolated yield (entry 12).…”
Section: Syn Thesismentioning
confidence: 99%
See 1 more Smart Citation
“…Further optimizations related to the amounts of DBU and phenyl isothiocyanate (entries 8-10) showed that the use of 3 equivalents of phenyl isothiocyanate allowed a significant improvement of the NMR yield (54%, entry 9). Afterwards, the dilution effect was examined (entries [11][12][13][14]. Optimal conditions using 0.1 M pyrazole 4c, DBU (1 equiv), and phenyl isothiocyanate (3 equiv) led to 7a in an improved 70% NMR yield and 45% isolated yield (entry 12).…”
Section: Syn Thesismentioning
confidence: 99%
“…Among them, the 1,3-thiazolidin-4-one core has been widely explored due to its versatile biological properties. [1][2][3] In particular, 2-iminothiazolidin-4ones I (Figure 1) display antifungal, [4][5][6] anti-inflammatory, 7,8 anticonvulsant, 9,10 hypnotic, 11 and antibacterial 6,12 activities. On the other hand, pyrazole scaffolds have also been largely exploited by medicinal chemists, leading to the development of valuable bioactive compounds.…”
mentioning
confidence: 99%
“…For a long time, thiazole derivatives were of great interest to scientists due to their significant and numerous pharmacological activities [ 5 ]. Thiazole derivatives have shown promise as therapeutic medicines such as anticancer [ 6 ], antimicrobial [ 7 ], antidiabetic agents [ 8 ], antiviral agents [ 9 ]. The fused imidazole was designed and drug discovery because it has a tremendous synthetic versatility that permits structural modifications throughout its periphery.…”
Section: Introductionmentioning
confidence: 99%
“…And finally, if morpholine subunit gets attached to a lipophillic scaffold it increases its bioavailability through oral administration by increasing aqueous solubility [15][16][17][18]. Likewise the chemistry of thiazolidine ring system is of considerable interest as it forms core structure of many biomolecules, commercial drugs [19]and synthetic molecules with promising antimicrobial, antifungal, anticancer and antidiabetic activity [20][21][22][23][24][25][26][27][28]. Combining multiple bioactive structural moieties into a single molecule usually complements the overall pharmacophoric performance and has been extensively used to design new drug candidates in structure based drug design [29,30].…”
Section: Introductionmentioning
confidence: 99%