PEG-400: An efficient and recyclable reaction medium for the synthesis of pyrazolo[1,5-a]pyrimidines

Konda, Shankaraiah G.

doi:10.5155/eurjchem.5.4.676-680.1110

Cited by 5 publications

(2 citation statements)

References 32 publications

(27 reference statements)

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“…As a part of our continuous work towards the exploration of polyethylene glycol (PEG-400) [36][37][38][39] as a green reaction solvent for the preparation of biologically active compounds, herein we report the synthesis of some new thienyl benzo[b]1,4-diazepines 2a-h by the condensation reaction of ophenylenediamine (o-PDA) with distinct hetero chalcones using NaOH in polyethylene glycol (PEG-400) as green reaction solvent. The starting compounds (hetero chalcones) 1a-h were prepared by our previously reported method (Scheme 1, Table 2) [40].…”

Section: Resultsmentioning

confidence: 99%

NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines

Mandawad¹,

Shaikh

Chobe³

et al. 2020

Eur J Chem

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A simple and eloquent procedure for the synthesis of a new series of thienyl benzo[b]1,4-diazepines is reported. They were synthesized by the condensation of o-phenylenediamine (o-PDA) with distinct hetero chalcones using NaOH in polyethylene glycol (PEG-400) as green and alternative reaction solvent. The significances of this present method are shorter reaction time, easy work-up, high yields, and mild reaction conditions. Furthermore, this method is environment friendly and without use of an expensive catalyst. The all newly synthesized compounds are characterized by the spectroscopic methods.

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Section: Resultsmentioning

confidence: 99%

NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines

Mandawad¹,

Shaikh

Chobe³

et al. 2020

Eur J Chem

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“…Because of potential utility of the chemistry in Scheme 1 in fine chemical industry it looked of value to optimize reaction conditions and confirmed concluded structures as only few pyrazolo [1,5-a]pyrimidine derivatives have been reported in the literature [9][10][11][12][13][14][15][16][17]. Although several pyrazolopyrimidine-7ones have been synthesized and tested for a variety of activities, only few isomeric-5-ones have ever been synthesized.…”

Section: -Arylazopyrazole-35-diamines (4) First Synthesized Bymentioning

confidence: 99%

Pressure as effective green technology for synthesis of polyfunctionally substituted heteroaromatics: Synthesis of a variety of pyrazolo[1,5-a]pyrimidines

et al. 2016

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Pyrazole molecules are in the forefront of organic chemistry due to their various encompass substituents, which have many biological activity sequence. The biological and medicinal activities of pyrazolo[1,5-a]pyrimidines have received considerable interest in this regard. We reported here a comparison between reaction of 4-phenylazo-3,5-diaminopyrazole (4) with ethyl propiolate (15), dimethylacetylene dicarboxylate (20), diethyl fumarate (25) and benzylidenemalononitrile (11) in the presence of catalytic amount of piperidine. We initially followed literature procedure (method A), then utilizing ultrasound irradiation (method B), microwave heating (method C) and in a Q-tube (method D). We confirmed the structure of the product by analytical spectroscopic methods. Method (D) gave a good yield with a record reaction time. KEYWORDS Q-tube High yields Record time Green technology Pyrazolo[1,5-a]pyrimidines Reactions under increased pressure

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One‐Pot S_NAr/Direct Pd‐Catalyzed CH Arylation Functionalization of Pyrazolo[1,5‐a]pyrimidine at the C3 and C7 Positions

et al. 2018

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An efficient and original synthesis of various 3,7‐substituted pyrazolo[1,5‐a]pyrimidines is reported. First, a two‐step process by an SNAr amination followed by a Pd‐catalyzed direct CH‐arylation was developed, then a parallel single‐pot SNAr amination/CH arylation sequence was performed starting from 7‐chloro‐5‐methyl‐2‐phenylpyrazolo[1,5‐a]pyrimidine to obtain highly functionalized products with good yields.

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PEG-400: An efficient and recyclable reaction medium for the synthesis of pyrazolo[1,5-a]pyrimidines

Cited by 5 publications

References 32 publications

NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines

NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines

Pressure as effective green technology for synthesis of polyfunctionally substituted heteroaromatics: Synthesis of a variety of pyrazolo[1,5-a]pyrimidines

One‐Pot S_NAr/Direct Pd‐Catalyzed CH Arylation Functionalization of Pyrazolo[1,5‐a]pyrimidine at the C3 and C7 Positions

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PEG-400: An efficient and recyclable reaction medium for the synthesis of pyrazolo[1,5-a]pyrimidines

Cited by 5 publications

References 32 publications

NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines

NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines

Pressure as effective green technology for synthesis of polyfunctionally substituted heteroaromatics: Synthesis of a variety of pyrazolo[1,5-a]pyrimidines

One‐Pot SNAr/Direct Pd‐Catalyzed CH Arylation Functionalization of Pyrazolo[1,5‐a]pyrimidine at the C3 and C7 Positions

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One‐Pot S_NAr/Direct Pd‐Catalyzed CH Arylation Functionalization of Pyrazolo[1,5‐a]pyrimidine at the C3 and C7 Positions