Characterization and biological activity studies on some transition metal complexes of thiosemicarbazide derived from 2-picolinic acid hydrazide

Mohamed, Eshraga Eltayeb; AbedelKarim, Abeer T.; Elmalik, Yahia Hassan; Mohamed, Amna Elamin; Aljahdali, Mutlaq Sheeded

doi:10.5155/eurjchem.5.2.252-259.990

Cited by 4 publications

(6 citation statements)

References 69 publications

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“…Although the synthesis and characterization of HL was previously reported [7], no information on NMR spectroscopic data has been provided. Such data obtained in this work validate the expected structure of the organic compound HL.…”

Section: Resultsmentioning

confidence: 99%

“…of picolinoyl (4-ethylthiosemicarbazide) (HL): HL was prepared by the procedure published [7]. Ethyl isothiocyanate (2.2 mL, 0.025 mol) was added dropwise to an ethanolic solution (40 mL) of picolinohydrazide (3.43 g, 0.025 mol).…”

Section: Synthesismentioning

confidence: 99%

“…Synthesis of the complex: The synthesis of the complex was performed by the procedure previously reported with some modifications [7]. Equimolar amounts of HL (22.4 mg, 0.1 mmol) and o-phenanthroline (18.0 mg, 0.1 mmol) were dissolved in 2 mL mixture of CH2Cl2/MeOH (1:1 v/v).…”

Section: Synthesismentioning

confidence: 99%

“…In this context, acyl thiosemicarbazides derived from picolinic acid are expected to be versatile (N, N, S)-tridentate ligands which can form stable complexes with various transition metal ions (Figure 2 b). Surprisingly, a survey of literature reveals only a few reports on synthesis and characterization of some transition metal complexes with picolinoyl thiosemicarbazides [5][6][7]. As part of our ongoing effort to explore the coordination chemistry of acyl thiosemicarbazides, we report herein, the facile synthesis and structure determination of a new heteroleptic Cu(II) complex with picolinoyl (4-ethylthiosemicarbazide).…”

Section: Introduction *mentioning

confidence: 99%

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Synthesis and Structural Characterization of Picolinoyl (4-ethylthiosemicarbazide) and its New Heteroleptic Cu(II) Complex

Huy¹,

Huy²,

Nguyet³

et al. 2022

NST

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The ligand picolinoyl(4-ethylthiosemicarbazide) HL was synthesized by the reaction of picolinohydrazide and ethyl isothiocyanate in absolute ethanol. The structure of HL was characterized by spectroscopic methods such as IR, 1H, and 13C NMR spectroscopy. One-pot reaction of CuCl2 and equimolar amounts of HL and o-phenanthroline in CH2Cl2/MeOH mixture with the presence of a supporting base like pyridine gave rise to a new heteroleptic cationic Cu(II) complex with the composition of [Cu(L)(o-phen)]+. Crystalline PF6– salt was obtained after workup with (n-Bu4N)(PF6) and single-crystal structure of the complex was determined. The spectroscopic data and X-ray crystallography demonstrated that the Cu(II) ion is five-coordinate with the coordination sphere consisted of (S, N1, Npyridine) and (N, N) donor sets belonging to the singly deprotonated ligand {L–} and o-phenanthroline, respectively.

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Section: Resultsmentioning

confidence: 99%

Section: Synthesismentioning

confidence: 99%

Section: Synthesismentioning

confidence: 99%

Section: Introduction *mentioning

confidence: 99%

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Synthesis and Structural Characterization of Picolinoyl (4-ethylthiosemicarbazide) and its New Heteroleptic Cu(II) Complex

Huy¹,

Huy²,

Nguyet³

et al. 2022

NST

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“…Transition metal complexes of Cu(II), Co(II), and Ni(II) 94a – c were prepared by refluxing an ethanolic solution of the thiosemicarbazone ligand 93 with 1,10-phenanthroline heterocyclic base with the metal salts ( Scheme 4 ). The reaction mixtures were refluxed on a water bath for 4 h and gave 85, 82, and 79% for Cu(II), Ni(II), and Co(II) complexes, respectively ( Scheme 47 ) [ 100 ]. The magnetic and spectral data indicate octahedral structures for all complexes.…”

Section: Metal Complexes Of Thiosemicarbazones and Thiocarbazonesmentioning

confidence: 99%

Transition Metal Complexes of Thiosemicarbazides, Thiocarbohydrazides, and Their Corresponding Carbazones with Cu(I), Cu(II), Co(II), Ni(II), Pd(II), and Ag(I)—A Review

et al. 2023

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: This review focuses on some interesting and recent applications of transition metals towards the complexation of thiosemicarbazides, thiocarbohydrazides, and their corresponding carbazones. We started the review with a description of the chosen five metals, including Cu[Cu(I), Cu(II], Co(II), Ni(II), Pd(II), and Ag(I) and their electronic configurations. The stability of the assigned complexes was also discussed. We shed light on different routes describing the synthesis of these ligands. We also reported on different examples of the synthesis of Cu(I), Cu(II), Co(II), Ni(II), Ag(I), and Pd(II) of thiosemicarbazide and thiocarbohydrazide complexes (until 2022). This review also deals with a summary of the fruitful use of metal complexes of thiosemicarbazones and thiocarbazones ligands in the field of catalysis. Finally, this recent review focuses on the applications of these complexes related to their biological importance.

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Novel thiosemicarbazone derivatives and their metal complexes: Recent development

Prajapati

Patel

2019

Synthetic Communications

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Characterization and biological activity studies on some transition metal complexes of thiosemicarbazide derived from 2-picolinic acid hydrazide

Cited by 4 publications

References 69 publications

Synthesis and Structural Characterization of Picolinoyl (4-ethylthiosemicarbazide) and its New Heteroleptic Cu(II) Complex

Synthesis and Structural Characterization of Picolinoyl (4-ethylthiosemicarbazide) and its New Heteroleptic Cu(II) Complex

Transition Metal Complexes of Thiosemicarbazides, Thiocarbohydrazides, and Their Corresponding Carbazones with Cu(I), Cu(II), Co(II), Ni(II), Pd(II), and Ag(I)—A Review

Novel thiosemicarbazone derivatives and their metal complexes: Recent development

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