IL-17 level in patients with acute myocardial infarction and its effect on lipid profile

Ibrahim, Ammal Esmaeel; Hasan, Hiba Ali; Jawad, Alaa H.

doi:10.5155/eurjchem.5.1.186-188.938

Cited by 1 publication

(1 citation statement)

References 23 publications

(22 reference statements)

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“…Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are the main fatty acids in fish oil [8]. Consumption of omega-3 supplements play an important role in reduction of CVD events and its associated mortality by ameliorating lipid profile via lowering triglyceride levels [9,10]. Furthermore, accumulating evidence reported that total cholesterol, LDL-C and HDL-C levels are improved by n-3 fatty acids consumption through increasing fatty acid oxidation and reducing VLDL production [11,12].…”

Section: Introductionmentioning

confidence: 99%

Effect of omega-3 supplementation on lipid profile in children and adolescents: a systematic review and meta-analysis of randomized clinical trials

Khorshidi

Hazaveh

Alimohammadi‐Kamalabadi

et al. 2023

Nutr J

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Purpose Dyslipidemia is considered as a known risk factor for cardiovascular disease. Yet various trials with wide ranges of doses and durations have reported contradictory results. We undertook this meta-analysis of randomized controlled trials (RCTs) to determine whether omega-3 supplementation can affect lipid profile in children and adolescents. Methods Cochrane Library, Embase, PubMed, and Scopus databases were searched up to March 2021. Meta-analysis was performed using random-effect method. Effect size was expressed as weighted mean difference (WMD) and 95% confidence interval (CI). Heterogeneity was assessed using the I2 index. In order to identification of potential sources of heterogeneity, predefined subgroup and meta-regression analysis was conducted. Results A total of 14 RCTs with 15 data sets were included. Based on the combination of effect sizes, there was a significant reduction in TG levels (WMD: -15.71 mg/dl, 95% CI: -25.76 to -5.65, P=0.002), with remarkable heterogeneity (I2=88.3%, P<0.001). However, subgroup analysis revealed that omega-3 supplementation significantly decreased TG only in studies conducted on participants ≤13 years old (WMD=-25.09, 95% CI: -43.29 to -6.90, P=0.007), (I2=84.6%, P<0.001) and those with hypertriglyceridemia (WMD=-28.26, 95% CI: -39.12 to -17.41, P<0.001), (I2=0.0%, P=0.934). Omega-3 supplementation had no significant effect on total cholesterol, HDL, and LDL levels. Also, results of nonlinear analysis showed significant effect of treatment duration on HDL status (Pnon-linearity=0.047). Conclusion Omega-3 supplementation may significantly reduce TG levels in younger children and those with hypertriglyceridemia. Also, based on the HDL-related results, clinical trials with longer duration of intervention are recommended in this population.

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