A new potentiometric sensor based on molecularly imprinted polymer for analysis of a veterinary drug imidocarb dipropionate

New Miniaturized Disposable Screen-Printed Microchip Integrated with Molecularly Imprinted Polymer for Metronidazole Benzoate Drug Detection

“…A molecularly imprinted polymer (MIP)-sensitive element was synthesized utilizing the precipitation polymerization methodology [25][26][27][28][29][30][31][32][33]. In such a method, MIP-based beads were obtained by incorporating 1.0 mmol metronidazole benzoate as a template drug molecule with 3.0 mmol of 1-vinyl-2-pyrrolidine (VP) monomer (Riedel-de Haën, Sleeze, Germany), 3.0 mmol of ethylene glycol dimethacrylate (EGDMA) (Riedel-de Haën, Sleeze, Germany)as a cross-linking agent and 60.0 mg of benzoyl peroxide (BPO) (Riedel-de Haën, Sleeze, Germany) as initiator.…”

“…Fourier-transform infrared (FT-IR ) spectroscopy (Brucker, Billerica, MA, USA) studies were conducted for the MIP metronidazole benzoate, NIP, and metronidazole benzoate template, and the results obtained are presented in Figure 1 While the three substances offered different spectra, the hydrogen bond formed between the imprinted polymer and the drug template appears in the spectra and clearly provides evidence for the interactions between the two molecules [33]. Specifically, the MIP and NIP FT-IR spectra showed a strong and broad peak at 3440 and 3448 cm −1 for νOH stretching and other peaks at 1690 and 1730 cm −1 for νC=O stretching, respectively, while the MIP spectrum also showed a broad O-H stretching peak at 3440 cm −1 , and CH stretching at 2967 cm −1 .…”

“…Moreover, a molecularly imprinted polymer (MIP) was recently applied as a sensitive element in the fabrication of potentiometric electrodes [13,[24][25][26][27][28][29][30][31][32][33]. MIP-sensitive elements represent novel materials and have appeared to be very promising candidates as highly selective membranes in potentiometric applications where analyte selectivity is crucial.…”

“…Recently, these MIPs yielded superior selectivity and consequently developed increased applicability in analytical chemistry, namely catalytic control, purification of racemic mixtures, and chemical sensing of complex species particularly drug species [8,13]. In this context, MIP materials have been used as a sensitive membrane in the fabrication of chemical sensors which have been successfully applied for the determination of illegal drugs and additives [26], lansoprazole detection [27], ivabradine hydrochloride quantifications [28], measurements of pharmaceutical and biological species [29], drug analysis [30], biomolecule sensing design to intraoral fluid testing [31], electrochemical sensors and electronic tongues [32], and the analysis of a veterinary drug, imidocarb dipropionate [33].…”

Molecularly Imprinted Polymers (MIPs) in Sensors for Environmental and Biomedical Applications: A Review

“…The sensor was tested in phosphate buffer solution (PBS) and selectivity, stability, and reproducibility were studied, with satisfactory results. A potentiometric sensor for the recognition of imidocarb dipropionate was synthesized by Rizk and coworkers [ 146 ], based on a potential difference between a MIP membrane sensor electrode and a reference electrode of Ag/AgCl. The prepolymerization solution was a mixture of the template, MAA, EGDMA, benzoyl peroxide, and acetonitrile that was bulk polymerized.…”