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Cited by 9 publications
(9 citation statements)
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“…The ESI mass spectrum (positive ion mode) of 4a revealed a (M+H) + ion at m/z 372. Based on the above spectral information the structure of the compound 4a was confirmed as (Z)-1-(4-(4,6-dichloro-1,3,5-triazin-2-ylamino)phenyl)-3-(phenyl)-2-propen-1-one [82][83][84].…”
Section: Synthesismentioning
confidence: 99%
“…The ESI mass spectrum (positive ion mode) of 4a revealed a (M+H) + ion at m/z 372. Based on the above spectral information the structure of the compound 4a was confirmed as (Z)-1-(4-(4,6-dichloro-1,3,5-triazin-2-ylamino)phenyl)-3-(phenyl)-2-propen-1-one [82][83][84].…”
Section: Synthesismentioning
confidence: 99%
“…It is important that considerable activity was observed when the hydroxyl groups are substituted at different positions on the phenyl ring as seen in the case of compounds 4k, 5h, 4e and 5e-5g and the order of activity was 4k (2-OH,3-Br,5-Cl, MIC : 6.25 µg/mL), 5h (2,5-diOH, MIC : 6.25 µg/mL) > 4e (3-OC2H5,4-OH, MIC: 25 µg/mL), 5e (2-OH, MIC: 25 µg/mL), 5f (4-OH, MIC: 25 µg/mL), 5g (2,4-diOH, MIC: 25 µg/mL) respectively. The compounds 5i (MIC: 50 µg/mL) and 5j (MIC: 50 µg/mL) having the methyl group substitution on the phenyl ring at position 5 along with the hydroxyl group substitution at 6 (5j) and 2 (5i) positions, respectively showed poorer level of inhibitory activity when compared with that of the compounds (5e-h) possessing only hydroxyl group substitution [69][70][71][72].…”
Section: Antitubercular Activitymentioning
confidence: 99%
“…Vasu Babu and co-workers, reported that the methyl substitution on ring 'A' of flavanone resulted in significant anti-tubercular activity against H37Rvstrain 10 Further, there were various substituted chalcones which exhibits potent lipoxygenase inhibitory activity 15 the effect few prenylated chalcones were investigated and multiple prenylated chalcones were found to become as lead compounds on 5-LOX inhibition 16,17 . Similarly, chalcones with methyl substitution on the aldehyde segment was observed to creates moderate inhibition on5-LOX and soyabeanlipoxygenase 18,19 .…”
Section: Introductionmentioning
confidence: 99%