Synthesis and biological evaluation of novel β-hydroxy benzimidazolyl sulfone fluoroquinolones by selective oxidation using ammonium molybdate catalysed H2O2

Guruswamy, B.; Arul, R.; Chaitan, Muggu Venkata Satya Rama Krishna; Darsi, Sai Subrahmanya Praveen Kumar

doi:10.5155/eurjchem.4.4.329-335.792

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…Aryl and diaryl sulfones has attracted much attention in agrochemicals, 1 medicinal chemistry, biological activities and provided (synthesis) numerous potent sulfone derivatives for different therapeutic (remedial) targets, for example, anti-inflammatory, 2,3 antimicrobial, 4,5 antiproliferative, 6,7 anticancer, 8 antimalarial, 9 cysteine protease inhibitors, 10,11 thyroid receptor ntagonist, 12 EPAC2 antagonist, 13 PI3K/Akt/mTOR signaling pathways inhibitors, 14 and γ-secretase inhibitors. 15 Also, aryl sulfones are found in various drugs such as 4,4 -diamino-diphenyl sulfone (dapsone) 16 and aryl pyrrolyl (and aryl indolyl) sulfones.…”

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confidence: 99%

Unsymmetrical Diaryl Sulfones through Electrochemical Oxidation of Fast Violet B in the Presence of Aryl Sulfinic Acids

Jamshidi

Nematollahi

Bayat

et al. 2016

J. Electrochem. Soc.

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Some new unsymmetrical diaryl sulfones were synthesized by anodic oxidation of fast violet B in aqueous/ethanol solutions in the presence of arylsulfinic acids at a carbon electrode. The data show that the electrogenerated N-acetyl-p-benzoquinone diimine was converted to the unsymmetrical diaryl sulfones by Michael type addition reaction with aryl sulfinic acids. This work has led to the development of a high yield, green, reagentless and facile electrochemical method for the synthesis of the described sulfones. In addition, four possible products were optimized at the BP86/def2-SVP level of theory by the parameters, natural charge, LUMO coefficient of Michael acceptor, thermodynamic and kinetic stability.

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confidence: 99%

Unsymmetrical Diaryl Sulfones through Electrochemical Oxidation of Fast Violet B in the Presence of Aryl Sulfinic Acids

Jamshidi

Nematollahi

Bayat

et al. 2016

J. Electrochem. Soc.

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“…These are widely used as antimicrobial agents, antidiabetic agents, diuretics, anticonvulsants, antiretroviral and Hepatitis-C antiviral agents. Several researches revealed that the broad spectrum antimicrobial activity of sulfone containing heterocycles entities [2][3][4][5][6][7][8][9][10] Recently, Kudruavtsev et al [11] reported that the sulfone bearing pyrrolidine derivatives inhibits Staphylococcus aureus sortase SrtA isoform, irreversibly by modification of enzyme cys 184.…”

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confidence: 99%

Synthesis of Sulfonated Dihydrofuropyrazoles Derivatives as Antimicrobial Active Agents

Tangeti

Satyanarayana

2019

Asian J. Chem.

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A series of sulfonyl dihydrofuropyrazole derivatives was prepared from one pot multi component condensation of sulfonated β-keto ester, aromatic aldehyde, hydrazine, pyridinium ylide in presence of piperidine catalyst under ethanol solvent conditions and subsequent oxidation of SPh group with MCPBA. All the synthesized compounds were characterized by analytical and spectral techniques and screened in vitro for antimicrobial activity. The activity data revealed that most of the compounds exhibited good to significant activities. Compounds 6b, 6i, 6j, 6k, 6m, 6n exhibited good and broad spectrum activity towards all the tested bacterial strains.

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Electrochemical generation of phenothiazin-5-ium. A sustainable strategy for the synthesis of new bis(phenylsulfonyl)-10H-phenothiazine derivatives

Mohamadighader,

Zivari-Moshfegh,

Nematollahi

2024

Sci Rep

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In this work, the electrochemical generation of phenothiazin-5-ium (PTZox) from the direct oxidation of phenothiazine (PTZ) in a water/acetonitrile mixture using a commercial carbon anode and conventional stainless steel cathode is reported. PTZox is a reactive intermediate with high potential synthetic applications, which is used in this paper for the synthesis of new phenothiazine derivatives. In this work a novel and simple electrochemical methodology for the synthesis of some bis(phenylsulfonyl)-10H-phenothiazine derivatives was established. In this paper, a mechanism for PTZ oxidation in the presence of arylsulfinic acids has been proposed based on the results obtained from voltammetric and coulometric experiments as well as spectroscopic data of the products. These syntheses are performed in a simple cell by applying constant current under mild conditions and at room temperature with high atom economy.

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Synthesis and biological evaluation of novel β-hydroxy benzimidazolyl sulfone fluoroquinolones by selective oxidation using ammonium molybdate catalysed H2O2

Cited by 5 publications

References 19 publications

Unsymmetrical Diaryl Sulfones through Electrochemical Oxidation of Fast Violet B in the Presence of Aryl Sulfinic Acids

Unsymmetrical Diaryl Sulfones through Electrochemical Oxidation of Fast Violet B in the Presence of Aryl Sulfinic Acids

Synthesis of Sulfonated Dihydrofuropyrazoles Derivatives as Antimicrobial Active Agents

Electrochemical generation of phenothiazin-5-ium. A sustainable strategy for the synthesis of new bis(phenylsulfonyl)-10H-phenothiazine derivatives

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