2013
DOI: 10.5155/eurjchem.4.2.146-148.756
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Abstract: A series of new curcumin analogues were obtained by Claisen-Schmidt condensation of substituted benzaldehydes with cyclohexanone derivatives using the ratio of 1:2 of ketone to aldehyde in dilute ethanolic solution under base catalyzed (NaOH) conditions at room temperature in good yields. The structures of the synthesized compounds were confirmed by data of IR, 1 H NMR, and 13 C NMR spectra.

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Cited by 7 publications
(7 citation statements)
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“…The α,β-unsaturated cyclohexanone derivatives, 2a-c, (Scheme 1) were obtained by condensation of cyclohexanone with substituted benzaldehydes, 1a-c, with excellent yields due to the stability of α,β-unsaturated cyclohexanone derivatives [41]. Compounds 2a [42] and 2b [37] were identified by comparing their 1 H and 13 C NMR spectral data with those reported in the cited references.…”
Section: Resultsmentioning
confidence: 99%
“…The α,β-unsaturated cyclohexanone derivatives, 2a-c, (Scheme 1) were obtained by condensation of cyclohexanone with substituted benzaldehydes, 1a-c, with excellent yields due to the stability of α,β-unsaturated cyclohexanone derivatives [41]. Compounds 2a [42] and 2b [37] were identified by comparing their 1 H and 13 C NMR spectral data with those reported in the cited references.…”
Section: Resultsmentioning
confidence: 99%
“…PDBA (0.2 g, 5.49 mmol) and hydrazine hydrate (0.18 mL, 0.3 mmol) in 5 mL glacial acetic acid [ 38 ] (Scheme 1) were taken in 25 mL round‐bottom flask and heated to 115 °C for 24 h. The content was cooled and poured into crushed ice, the resulting precipitate was filtered, and then reprecipitated with MeOH. The polymer was characterized by 1 H NMR (see Figure S6, Supporting Information).…”
Section: Methodsmentioning
confidence: 99%
“…Numerous , 0 -bis(substitutedbenzylidene)cycloalkanones exhibit biological activities (Robinson et al, 2005;Piantadosi et al, 1973). Furthermore, they are used as precursors for the preparation of biologically active heterocyclic compounds, such as pyrimidines (Deli et al, 1984;Guilford et al, 1999) and pyrazolines (Ziani et al, 2013). These compounds have received a lot of attention because of their uses as perfume intermediates, pharmaceutical, agrochemical and liquid-crystal polymer units (Artico et al, 1998;Amoozadeh et al, 2010).…”
Section: Chemical Contextmentioning
confidence: 99%