Synthesis and spectral characterization of some heterocyclic nitrogen compounds

Abstract

KEYWORDSQuinazolines and pyrimidines are most important class of compounds and have received much attention from both synthetic and medicinal chemists, because of the diverse range of their pharmacological properties. Owing to their versatile chemotherapeutic importance, a number of quinazolin-2,4-dione derivatives were synthesized using appropriate synthetic routes and characterized by IR, 1 H NMR, MS, and elemental analysis.Arylidine Hydrazide Pyrimidines Carbon disulphide Quinazolin-2,4-dione Glycine ethyl ester hydrochloride

Synthesis, Characterization, Antibacterial Activity, and Computer-Aided Design of Novel Quinazolin-2,4-dione Derivatives as Potential Inhibitors Against Vibrio cholerae

“…The synthetic strategy pathway for synthesis of hydrazide 1 is reported earlier in previous works. [18][19][20][21] Then, compound 1 was used as starting material for synthesis of new compounds 2 to 8 as declared in Scheme 1. Furthermore, the new heterocyclic moiety pyrazole in compound 2 was prepared via Knorr pyrazole synthesis by treatment of compound 1 with β-di-ketone such as acetylacetone in 79% yield as reported in Scheme 2.…”

Utility of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide in the synthesis of some heterocyclic nitrogen compounds

“…In this work, we were able to introduce the amino group which is present in glycine ethyl ester hydrochloride into the sulphonyloxy system in N-phenylsulphonyloxyphthalimide 1 to obtain (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid ethyl ester 2 which on treatment with hydrazine hydrates in ethanol gave the hydrazide 3 (Scheme 1) [12]. Scheme 4 outlines the synthetic pathway used to obtain (2,4-dioxo-1,4dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide 3 [12].…”

“…Scheme 4 outlines the synthetic pathway used to obtain (2,4-dioxo-1,4dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide 3 [12]. The route outlined in Scheme 2 shown that hydrazide 3 used as a starting material for synthesis of some new quinazoline derivatives attached to interesting heterocycles such as triazole, oxadiazole, pyrazole and phthalazine rings which have biological effects [13,14], and many applications were they are used as fungicidal and bacterial reagents [15].…”

Novel Quinazolin-2,4-Dione Hybrid Molecules as Possible Inhibitors Against Malaria: Synthesis and in silico Molecular Docking Studies

“…All the prepared compounds were analyzed for C, H, and N at Cairo University, Egypt. Compounds 1 and 9 were already described (Hassan et al, 2013a).…”