2013
DOI: 10.5155/eurjchem.4.1.35-43.713
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Abstract: KEYWORDSSeveral simple, sensitive, accurate and inexpensive spectrophotometric and spectrofluorimetric methods were developed for the determination of propafenone HCl and diltiazem HCl using 4-chloro-7-nitrobenzofurazan (NBD-Cl) accompanied with kinetic study, either in pure form or in pharmaceutical preparations. In this work, the cited drugs react with (NBD-Cl) in presence of borate buffer of pH = 7.6 at a fixed time of 30 minutes on thermostated water bath at (75-80 °C). The absorbance was measured using sp… Show more

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Cited by 10 publications
(8 citation statements)
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“…Some of the reported methods have limitations such as time-consuming procedures, interference from substances and/or relatively high cost of instrumentation. Kinetic spectrophotometry methods have comparable levels of accuracy and sensitivity to the methods above mentioned and have been used in the quantification of different pharmaceutical analytes in different matrices [39][40][41][42][43]. In these methods, the absorbance variation in the time is measured under nonequilibrium conditions.…”
Section: Diphenhydraminementioning
confidence: 99%
“…Some of the reported methods have limitations such as time-consuming procedures, interference from substances and/or relatively high cost of instrumentation. Kinetic spectrophotometry methods have comparable levels of accuracy and sensitivity to the methods above mentioned and have been used in the quantification of different pharmaceutical analytes in different matrices [39][40][41][42][43]. In these methods, the absorbance variation in the time is measured under nonequilibrium conditions.…”
Section: Diphenhydraminementioning
confidence: 99%
“…Conventionally, it is a measure of the change in concentration of the chemical species as function of time by using UV-Vis spectrophotometry [12][13][14]. This fact opens a research challenge in the analytical chemistry that addresses the development of simple, inexpensive and accurate methods with a performance as good as sophisticated methods.…”
Section: Introductionmentioning
confidence: 99%
“…Few analytical methods have been reported for the determination of NAF in biological fluids and/or pharmaceutical preparations. Most of these studies focused on HPLC-UV detection [3][4][5], HPLC-fluorescence detection [6,7] and phosphorimetric analysis [8,9] Others included potentiometric methods using NAF ion-selective electrodes [10,11] flow injection analysis with fluorescence opti-sensor [12], spectrophotometric, spectrofluorimetric and voltammetric analyses in tablets [13], a spectrophotometric method using complexation reactions [14] and kinetic spectrophotometric method using alkaline potassium permanganate were described [15]. Also stability indicating methods were reported for the determination of the drug [16,17].…”
Section: Introductionmentioning
confidence: 99%