2012
DOI: 10.5155/eurjchem.3.4.447-454.681
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Abstract: KEYWORDSSimple, selective and precise spectrophotometric methods were adopted for simultaneous determination of sitagliptin (SIT) and simvastatin (SIM) in new co-formulated pharmaceutical dosage form. In the first method, SIT was determined by measuring its zero order absorbance at 266.4 nm in the range of 40-360 µg/mL in the presence of up to 70% of SIM. While, the two cited drugs were determined simultaneously using third derivative method by measuring the sum of peak amplitudes (peak & valley) at 275.3-280.… Show more

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Cited by 4 publications
(3 citation statements)
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“…Absorption spectrophotometric methods were applied to quantify active pharmaceutical ingredients (API) in pharma-ceutical preparations but this technique had the problem that most drugs absorb in the ultra violet region and so a strong spectra overlapping was noticed [15]. Severe overlapping was observed between the zero order absorption spectra (D 0 ) of SFV and LDI in the same proportion used in tablet manufacture (Figure 1).…”
Section: Resultsmentioning
confidence: 99%
“…Absorption spectrophotometric methods were applied to quantify active pharmaceutical ingredients (API) in pharma-ceutical preparations but this technique had the problem that most drugs absorb in the ultra violet region and so a strong spectra overlapping was noticed [15]. Severe overlapping was observed between the zero order absorption spectra (D 0 ) of SFV and LDI in the same proportion used in tablet manufacture (Figure 1).…”
Section: Resultsmentioning
confidence: 99%
“…Upon surveying the literature, various methods were reported for the simultaneous determination of sitagliptin and simvastatin, spectrophotometrically [11–14], RP‐HPLC [15–19], and HPTLC [20], and they have been assayed in human plasma by LC–MS/MS [21]. To the best of the authors' knowledge, there is no capillary electrophoretic analytical method yet reported for the simultaneous determination of the cited drugs in their binary mixture.…”
Section: Introductionmentioning
confidence: 99%
“…These methods include the use of spectrophotometric methods [18,19] and chromatographic methods [20,21].…”
Section: Introductionmentioning
confidence: 99%