2012
DOI: 10.5155/eurjchem.3.4.406-410.476
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Abstract: KEYWORDSFive new compounds, bis-pyrazoline derivatives (2a-e) with antibacterial properties, built around the alkyl chains of varying lengths were prepared via reaction of various 1-ω-alkoxybis-chalcones with N-substituted thiosemicarbazide in ethanolic NaOH solution. The antibacterial activity of these compounds were evaluated by the disk diffusion method against two Gram-positive and two Gram-negative bacteria and the minimum inhibitory concentration were determined. The structures of these compounds were el… Show more

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“…2-Pyrazolines (4,5-dihydro-1H-pyrazole) are an important class of five-membered heterocyclic compounds and were found to be vital building blocks in medicinal chemistry and led to the discovery of a number of bioactive derivatives [1,2]. 2-Pyrazolines were considered as a cyclic hydrazine moiety [3].…”
Section: Introductionmentioning
confidence: 99%
“…2-Pyrazolines (4,5-dihydro-1H-pyrazole) are an important class of five-membered heterocyclic compounds and were found to be vital building blocks in medicinal chemistry and led to the discovery of a number of bioactive derivatives [1,2]. 2-Pyrazolines were considered as a cyclic hydrazine moiety [3].…”
Section: Introductionmentioning
confidence: 99%