Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate

Ayad, Magda M.; Abdellatef, Hisham E.; Hosny, Mervat M.; Sharaf, Yassmin Ahmed

doi:10.5155/eurjchem.3.3.332-336.637

Cited by 10 publications

(5 citation statements)

References 27 publications

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“…The unique pharmacokinetic and pharmacodynamic characteristics of AMD seem to be linked to its physicochemical features, particularly its high degree of ionization and basicity [14]. Several methods have been conducted to determine AMD alone and with other drugs in its pure form and commercial samples: the redox titrimetric method [15], spectrophotometric methods [16][17][18], spectrofluorimetric methods [17,[19][20][21][22][23][24][25][26][27][28], high-performance liquid chromatography [29][30][31][32], thin layer chromatography [30], electroanalytical methods [31,33], and capillary electrophoretic methods [34,35]. Kokilambigai et al have provided a good review of the different analytical methods for determining AMD [36].…”

Section: Introduction and Prefacementioning

confidence: 99%

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Alqarni,

Haredy,

Abdelrahman

et al. 2024

Luminescence

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The suggested study adheres to a particular protocol to ensure that the process is environmentally friendly and sustainable. It is worth mentioning that several tools have been adopted as prospective measures of the method greenness. Fortunately, the established analytical method is identified as white by the white analytical chemistry (WAC) concept, which uses the red/ green/blue color scheme (RGB 12 tool) to combine ecological and functional factors for the first time in studying of the cited drug. Amlodipine (AMD), a cardiovascular treating agent, belongs to the dihydropyridine class of oral calcium channel‐blocking agents. This article presents a novel, simple, green, one‐pot‐processed, fast, and ultrasensitive fluorimetric approach for monitoring and assessment of AMD using molecular‐size‐dependent fluorescence augmentation of the light scattering‐driven signal of eosin, a biological stain at a wavelength of 415 nm. This enhancement was directly proportional to the size of the produced complex. The linearity range was from 30 to 900 ng mL−1, with corresponding sensitivity limits (detection and quantitation levels) of 9.2 and 28 ng mL−1, respectively. The planned approach was also successfully used to track AMD content in bulk, dosage forms, and bio‐fluids (human plasma and urine). The developed method's eco‐friendliness was established by different eco‐rating metric tools.

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Section: Introduction and Prefacementioning

confidence: 99%

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Alqarni,

Haredy,

Abdelrahman

et al. 2024

Luminescence

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“…where, Ω -1 Correct and Ω -1 Obs are the corrected electrolytic conductivity and the observed electrolytic conductivity, respecttively, v1 represents the initial volume and v2 represents the volume of NaOH and KOH added [26]. The equivalence point was determined by plotting a graph between corrected conductivity and volume of NaOH and KOH added for Method A and Method B, respectively.…”

Section: Methods Bmentioning

confidence: 99%

Conductometric determination of naproxen in bulk and pharmaceutical dosage form

Alhazmi

Bratty

2017

Eur. J. Chem.

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This study aimed at the development of simple and cheap conductometric method that can be used for the determination of naproxen in bulk and dosage forms. During the study, naproxen was titrated with sodium hydroxide (Method A) and potassium hydroxide (Method B) and the end points were determined with conductivity cell. Variables affecting the end point determination were also studied in the range of 1-10 mg/mL of naproxen. The proposed methods were validated by precision and recovery studies. The percentage recoveries ranged from 99.15±0.659 and 101.13±0.543 with % RSD of 0.897 and 0.749 with sodium hydroxide and potassium hydroxide, respectively. The methods were effectively applied for the determination of naproxen in tablet dosage form. The methods proposed in this study can be used as substitute for more composite and classy methods used for the determination of naproxen and are highly reproducible as compared to other reported methods. KEYWORDS

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“…Hossein Heli and co-authors determined sotalol amperometrically [11]. Conductometric titration with a solution of argentum nitrate sotalol hydrochloride in the substance and drugs is described [12]. Fawzia A. Ibrahim and co-authors proposed a sensitive method of spectrofluorimetric determination of sotalol in dosage forms and plasma by its own fluorescence [13].…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric methods for quantitative determination of sotalol in tablets

Maletska

Vasyuk

2022

SR: PS

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The aim of the work. To develop a method for spectrophotometric determination of sotalol with diazonium salts. Establish optimal conditions for the quantitative determination of sotalol in drugs. Validate the developed methodology. Materials and methods. Reagents and solvents used in the study were: diazole red 2J (obtained from NVF “Sinbias”), tablets “Sotalol Sandoz” 40 mg (Salyutas Pharma GmbH, series JZ1188), “Sotalol Sandoz” 80 mg (Salyutas Pharma GmbH, series KA0464) and “Sotalol Sandoz” 160 mg (Salyutas Pharma GmbH, series JY3504), methanol (LAB-SCAN, Ireland, batch № 5120/13), sodium carbonate (Sinbias) and purified water were also used. Analytical equipment: spectrophotometer “SPECORD-200” (Analytic Jena AG, Germany), scales laboratory electronic RADWAG XA 210.4Y, bath ultrasonic Sonorex Digitec DT100H, laboratory glassware of class A. All studies were conducted in the experimental pharmaceutical research department of the scientific medical laboratory center (SMLC) of the Zaporizhzhia State Medical University. Results and discussion. The technique of spectrophotometric determination of the quantitative content of sotalol based on its reaction with red diazole in water-methanol medium has been developed. The stoichiometric ratios of the reactive components as 1:1 were obtained by the methods of continuous changes and the saturation method. Validation of the developed on such indicators as linearity, precision, correctness and robustness is carried out. Based on these data, the developed method is correct and could be used in the quality control departments of chemical and pharmaceutical companies. Conclusions. A method of quantitative spectrophotometric determination of sotalol in the tablet dosage form “Sotalol Sandoz” 40 mg, “Sotalol Sandoz” 80 mg and “Sotalol Sandoz” 160 mg of industrial production was developed, validation characteristics were investigated: linearity, precision, correctness, range of application and robustness

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Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate

Cited by 10 publications

References 27 publications

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Conductometric determination of naproxen in bulk and pharmaceutical dosage form

Spectrophotometric methods for quantitative determination of sotalol in tablets

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