Synthesis and studies of pyrazolo[3,4-b]piperidin-4-one derivatives

Synthesis and studies of pyrazolo[3,4-b]pyridin-4-one derivatives

“…Our approach to the development of some synthetic applications of 1-phenyl-3-methyl-5-pyrazolone is based on the generation of building blocks containing fused, isolated, and Spiro heterocyclic compounds, each of which can be selectively reacted [51]. We have recently shown like reaction of 1-(5imino-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)ethanone (1) wheras we have obtained an available compound 2, Scheme 1.…”

“…The pyrazole nucleus is present in a wide variety of biologically interesting compounds, which exhibit anti-hyperglycemic, analgesic, anti-inflammatory, antipyretic, antibacterial, hypoglycemic, sedative-hypnotic activity [29][30][31][32][33][34][35][36][37][38][39][40][41][42]. Pyrazoles and their derivatives are widely used as pharmaceutical [43][44][45] and agrochemical agents [46] and consequently a large number of synthetic routes to pyrazoles has been reported [47][48][49][50][51]. However, there is still great interest in finding milder and more efficient methods to these valuable compounds.…”

An update on the synthesis and reactivity of spiro-fused β-lactams

“…Pyrazoline 21 was derived from 4-acetyl-5-imino-3-methyl-1-phenyl-2-pyrazoline 20 by a reductive reaction using Zn/AcOH. 27 Anand and co-workers 28 have reported the facile synthesis of axial and equatorial spiro-β-lactams 26 via the entrapment of cyclohexanone imines 25 with acetoxyacetyl chloride in a [2+2]-cyclocondensation at -78°C (Scheme 7). The resulting conformations of 4-substituted 1-azaspiro [3.5]nonan-2-ones 26, which could be isolated as stable, pure crystals, were confirmed by X-ray crystallography.…”

Synthesis and Characterization of 1,3,5-Trisubstituted Pyrazoline Derivatives by Ultrasonic Irradiation Method and Evaluation of its Antibacterial Activity

“…A large number of organic reactions can be carried out in a higher yield shorter reaction time and milder conditions under ultrasound 9 . Pyrazoles and their derivatives are widely used as pharmaceutical [10][11][12] and agrochemical agents 13 and consequently a large number of synthetic routes to pyrazoles has been reported [14][15][16][17][18] In view of these observations and in continuation of our research programme on the synthesis of five-membered heterocyclic compounds, we report herein the synthesis of some pyrazoline derivatives from substituted chalcone using ultrasonic irradiation , which have been found to possess an interesting profile of antimicrobial activity. …”