Cytotoxic and antioxidant effects of grape seed oil on the treatment of leukemia with methotrexate

Şahin, Nefise Özlen; Berköz, Mehmet; Eker, Ebru Derici; Pomierny, Bartosz; Przejczowska, Katarzyna

doi:10.5155/eurjchem.3.2.147-151.569

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…The antioxidant potential of yuzu seed oil was measured by utilizing the reduction reaction of copper (Cu ++ / Cu + ) to calculate the total potential anti-oxidant capacity. 29 Many other plant oils, including olive oil, 39 grapefruit seed oil, 40 grape seed oil, 41 and neem seed oil, 42 that are known to have strong antioxidant activity were measured at the same time to give a comparison. Among all the plant seed oils tested, yuzu and neem seed oils showed the highest antioxidant capacity, followed by grape seed and olive oils.…”

Section: Evaluating the Activity Of Compounds Extracted From Yuzu Seedsmentioning

confidence: 99%

The functional evaluation of waste yuzu (Citrus junos) seeds

Minamisawa

Yoshida²,

Uzawa

2014

Food Funct.

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We have succeeded in extracting a large amount of expensive limonoids and the high total antioxidant capability yuzu seed oil from waste yuzu seed by simple methods. Yuzu seeds contain higher amounts of fat-soluble limonoid aglycone (330.6 mg g(-1) of dry seed), water-soluble limonoid glycoside (452.0 mg g(-1) of dry seed), and oil (40 mg g(-1) of green seed) than other citrus fruits. The antioxidant activities of yuzu seed aglycone, glycoside, and seed oil were evaluated in vitro. The potential antioxidant activity in oil solution, diphenylpicrylhydrazyl radical-scavenging activity, and hydrogen peroxide-scavenging activity effects of the seed extracts were also investigated. The antioxidant activity of yuzu seed oil was two times that of grapefruit seed oil, which has high activity. Yuzu glycoside produced the same high antioxidant activity as Luo Han Guo glycoside.

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Section: Evaluating the Activity Of Compounds Extracted From Yuzu Seedsmentioning

confidence: 99%

The functional evaluation of waste yuzu (Citrus junos) seeds

Minamisawa

Yoshida²,

Uzawa

2014

Food Funct.

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“…Seeds are most often used for extraction of OPCs (oligomeric procyanidins) (Bourzeix et al, 1986;Sun et al, 1999a;Spranger et al, 2008), whereas skins and stems are also used for preparation of grape resveratrol extracts (Sun et al, 2006). Moreover, seeds are also used for extraction of oil, which is potentially very health-beneficial because it is one of the richest sources of unsaturated fat (Sahin et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Extraction Yields and Anti‐oxidant Activity of Proanthocyanidins from Different Parts of Grape Pomace: Effect of Mechanical Treatments

Sá

Justino

Spranger

et al. 2013

Phytochemical Analysis

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“…The total potential antioxidant capacity of yuzu seed oil and lipophilic limonoid aglycones was measured by utilizing the reduction reaction of copper (Cu ++ /Cu + ) [35]. Many other plant oils, including olive oil [36], tea tree oil, grape seed oil [37], and neem seed oil [38], which have strong antioxidant activities, were measured at the same time for comparisons. Among all of the tested plant seed oils, limonoid aglycones extracted from yuzu seeds had the highest antioxidant capacity, followed by yuzu seed oil, neem seed, grape seed, tea tree, olive oil, and pure yuzu seed oil.…”

Section: Figurementioning

confidence: 99%

Physiological Functions Mediated by Yuzu (Citrus junos) Seed-Derived Nutrients

Minamisawa¹

2021

Citrus - Research, Development and Biotechnology

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This section is focused on the physiological functions of yuzu (Citrus junos) to improve health. The modern lifestyle involves number of modern lifestyles involve various factors that may increase the production of active oxygen species. Nutritional supplements and medicines are commonly utilized to maintain health. Yuzu seeds contain >100-fold the limonoid content of grapefruit seeds and are rich in polyamines (PAs), including putrescine, spermidine, and spermine. Limonoid components mediate the antioxidant properties of citrus. Limonoids and PAs convey various bioactivities. PAs are closely associated with maintaining the function of the intestinal mucosal barrier, which might be involved in the metabolic processes of indigenous intestinal bacteria and in the health of the host. After ingestion, food is digested and absorbed in the intestinal tract, which is also responsible for immune responses against food antigens and intestinal bacteria. Detailed investigations of the physiological functions of extracted yuzu seed extracts may help to develop new treatment strategies against diseases associated with inflammatory responses.

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Cytotoxic and antioxidant effects of grape seed oil on the treatment of leukemia with methotrexate

Cited by 6 publications

References 29 publications

The functional evaluation of waste yuzu (Citrus junos) seeds

The functional evaluation of waste yuzu (Citrus junos) seeds

Extraction Yields and Anti‐oxidant Activity of Proanthocyanidins from Different Parts of Grape Pomace: Effect of Mechanical Treatments

Physiological Functions Mediated by Yuzu (Citrus junos) Seed-Derived Nutrients

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