Synthesis and biological activity of functionalized phosphorus derivatives of isatin imines

Abstract

KEYWORDSIsatin-3-imine derivatives (1a-d) have been synthesized. These compounds were then converted into phosphorylated products 2a, 2c with triethylphosphite and 3a-d with triphenylphosphine. The structures of the new compounds were confirmed by elemental analyses, IR, UV/VIS, 1 H NMR, 13 C NMR and MS studies. The structure of compound 1a was also confirmed by single crystal X-ray diffraction studies. Compounds 1b-d and 3c-d exhibited potent antibacterial activity against Bacillus subtilis and Escherichia Coli. Compound 3a was found to exhibit antifungal activity against the tested organisms.Mass spectroscopy Phosphorylation Triphenylphosphine Schiff bases X-ray crystallography Antimicrobial activity

Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin

“…Very recently, we have reported the synthesis of novel xanthene based imine derivatives showing excellent antibacterial activity [18]. Inspired with biological activities possessed by imines [19][20][21][22][23] and amoxicillin, an endeavor was made to manufacture novel imine derivatives (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) of amoxicillin by condensing it with different aldehydes and ketones. The novel amoxicillin imine derivatives were characterized well by different spectroscopic techniques and screened for antimicrobial activities.…”

Nitroisatin dithiocarbazate: Synthesis, structural characterization, DFT, and docking studies

“…This configuration allows many modifications in its structure, such as addition of halogen atoms at C5 and C7 positions of the aromatic ring and alkylation/ acylation at N-H group which may lead to modifications of its chemical properties [1]. Isatins and their derivatives are known to have a broad spectrum of pharmacological applications such as antifungal, antibacterial, antiviral, antitumor, and antiprotozoal [2][3][4]. Besides, isatin is a biologically validated as an inhibitor of cysteine and serine proteases [5], being an interesting starting point for the design and synthesis of new compounds with potential for applications in medicine, mainly Schiff bases such as hydrazones, thiosemicarbazones, dithiocarbazates (Figure 1b, 1c and 1d, respectively) and also some of their metal complexes.…”

Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives

“…it is active against a wide range of Gram-positive, and a limited range of Gram-negative organisms [2]. It is also found that amoxicillin and its derivatives are very importance in many research studies, such as pharmaceutical and biological studies [3][4][5][6].…”