Synthesis and antimicrobial activity of novel oxime derivatives of phenothiazine

The Copper-Catalyzed Reaction of 2-(1-Hydroxyprop-2-yn-1-yl)phenols with Sulfonyl Azides Leading to C3-Unsubstituted N-Sulfonyl-2-iminocoumarins

“…Indeed, a number of them have considerable therapeutic potential. One subset of such compounds are the C3-unsubstituted iminocoumarins (Figure ) that have been explored as enzyme inhibitors (e.g., 1 ) including, potentially, of acetylcholine esterase (AChE) ( 2 ), as antimicrobial agents ( 3 ), as antitumor agents ( 4 ), and as antifungals ( 5 ) . Consequently, there is an attendant interest in the development of flexible and concise new routes to such systems.…”